Molecular Effects of Elongation Factor Ts and Trigger Factor on the Unfolding and Aggregation of Elongation Factor Tu Induced by the Prokaryotic Molecular Chaperone Hsp33

Molecular Effects of Elongation Factor Ts and Trigger Factor on the Unfolding and Aggregation of Elongation Factor Tu Induced by the Prokaryotic Molecular Chaperone Hsp33

Hsp33, a prokaryotic redox-regulated holding chaperone, has been recently identified to be able to exhibit an unfoldase and aggregase activity against elongation factor Tu (EF-Tu) in its reduced state. In this study, we investigated the effect of elongation factor Ts (EF-Ts) and trigger factor (TF)...

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Bibliographic Details
Main Authors: Minho Keum, Dai Ito, Mi-Seong Kim, Yuxi Lin, Kyeong-Hyeon Yoon, Jihoon Kim, Sung-Hee Lee, Ji-Hun Kim, Wookyung Yu, Young-Ho Lee, Hyung-Sik Won
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Biology
Subjects:
aggregase activity
EF-Tu
EF-Ts
proteostasis
Hsp33
molecular chaperone
Online Access:https://www.mdpi.com/2079-7737/10/11/1171

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