Multifunctional Iron Bound Lactoferrin and Nanomedicinal Approaches to Enhance Its Bioactive Functions
Lactoferrin (Lf), an iron-binding protein from the transferrin family has been reported to have numerous functions. Even though Lf was first isolated from milk, it is also found in most exocrine secretions and in the secondary granules of neutrophils. Antimicrobial and anti-inflammatory activity rep...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-05-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/6/9703 |
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| author | Jagat R. Kanwar Kislay Roy Yogesh Patel Shu-Feng Zhou Manju Rawat Singh Deependra Singh Muhammad Nasir Rakesh Sehgal Alka Sehgal Ram Sarup Singh Sanjay Garg Rupinder K. Kanwar |
| author_facet | Jagat R. Kanwar Kislay Roy Yogesh Patel Shu-Feng Zhou Manju Rawat Singh Deependra Singh Muhammad Nasir Rakesh Sehgal Alka Sehgal Ram Sarup Singh Sanjay Garg Rupinder K. Kanwar |
| author_sort | Jagat R. Kanwar |
| collection | DOAJ |
| description | Lactoferrin (Lf), an iron-binding protein from the transferrin family has been reported to have numerous functions. Even though Lf was first isolated from milk, it is also found in most exocrine secretions and in the secondary granules of neutrophils. Antimicrobial and anti-inflammatory activity reports on lactoferrin identified its significance in host defense against infection and extreme inflammation. Anticarcinogenic reports on lactoferrin make this protein even more valuable. This review is focused on the structural configuration of iron-containing and iron-free forms of lactoferrin obtained from different sources such as goat, camel and bovine. Apart for emphasizing on the specific beneficial properties of lactoferrin from each of these sources, the general antimicrobial, immunomodulatory and anticancer activities of lactoferrin are discussed here. Implementation of nanomedicinial strategies that enhance the bioactive function of lactoferrin are also discussed, along with information on lactoferrin in clinical trials. |
| first_indexed | 2024-04-13T14:19:49Z |
| format | Article |
| id | doaj.art-6f6a43fffb8c4535b4f14082476102be |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T14:19:49Z |
| publishDate | 2015-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6f6a43fffb8c4535b4f14082476102be2022-12-22T02:43:30ZengMDPI AGMolecules1420-30492015-05-012069703973110.3390/molecules20069703molecules20069703Multifunctional Iron Bound Lactoferrin and Nanomedicinal Approaches to Enhance Its Bioactive FunctionsJagat R. Kanwar0Kislay Roy1Yogesh Patel2Shu-Feng Zhou3Manju Rawat Singh4Deependra Singh5Muhammad Nasir6Rakesh Sehgal7Alka Sehgal8Ram Sarup Singh9Sanjay Garg10Rupinder K. Kanwar11Nanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine (SoM), Molecular and Medical Research (MMR) Strategic Research Centre, Faculty of Health, Deakin University, Waurn Ponds, Victoria 3217, AustraliaNanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine (SoM), Molecular and Medical Research (MMR) Strategic Research Centre, Faculty of Health, Deakin University, Waurn Ponds, Victoria 3217, AustraliaNanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine (SoM), Molecular and Medical Research (MMR) Strategic Research Centre, Faculty of Health, Deakin University, Waurn Ponds, Victoria 3217, AustraliaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL 33612, USAUniversity Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur 492 010, IndiaUniversity Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur 492 010, IndiaDepartment of Food Science & Human Nutrition, Faculty of Bio-Sciences, University of Veterinary & Animal Sciences, Lahore, Punjab 54000, PakistanDepartment of Medical Parasitology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaDepartment of Obstetrics & Gynecology, Government Medical College & Hospital, Sector 32, Chandigarh 160031, IndiaCarbohydrate and Protein Biotechnology Laboratory, Department of Biotechnology, Punjabi University, Patiala 147002, IndiaCentre for Pharmaceutical Innovation and Development (CPID), School of Pharmacy and Medical Sciences, University of South Australia, Adelaide SA 5000, AustraliaNanomedicine-Laboratory of Immunology and Molecular Biomedical Research (NLIMBR), School of Medicine (SoM), Molecular and Medical Research (MMR) Strategic Research Centre, Faculty of Health, Deakin University, Waurn Ponds, Victoria 3217, AustraliaLactoferrin (Lf), an iron-binding protein from the transferrin family has been reported to have numerous functions. Even though Lf was first isolated from milk, it is also found in most exocrine secretions and in the secondary granules of neutrophils. Antimicrobial and anti-inflammatory activity reports on lactoferrin identified its significance in host defense against infection and extreme inflammation. Anticarcinogenic reports on lactoferrin make this protein even more valuable. This review is focused on the structural configuration of iron-containing and iron-free forms of lactoferrin obtained from different sources such as goat, camel and bovine. Apart for emphasizing on the specific beneficial properties of lactoferrin from each of these sources, the general antimicrobial, immunomodulatory and anticancer activities of lactoferrin are discussed here. Implementation of nanomedicinial strategies that enhance the bioactive function of lactoferrin are also discussed, along with information on lactoferrin in clinical trials.http://www.mdpi.com/1420-3049/20/6/9703lactoferrincamelbovineimmunitycancernanoparticles |
| spellingShingle | Jagat R. Kanwar Kislay Roy Yogesh Patel Shu-Feng Zhou Manju Rawat Singh Deependra Singh Muhammad Nasir Rakesh Sehgal Alka Sehgal Ram Sarup Singh Sanjay Garg Rupinder K. Kanwar Multifunctional Iron Bound Lactoferrin and Nanomedicinal Approaches to Enhance Its Bioactive Functions Molecules lactoferrin camel bovine immunity cancer nanoparticles |
| title | Multifunctional Iron Bound Lactoferrin and Nanomedicinal Approaches to Enhance Its Bioactive Functions |
| title_full | Multifunctional Iron Bound Lactoferrin and Nanomedicinal Approaches to Enhance Its Bioactive Functions |
| title_fullStr | Multifunctional Iron Bound Lactoferrin and Nanomedicinal Approaches to Enhance Its Bioactive Functions |
| title_full_unstemmed | Multifunctional Iron Bound Lactoferrin and Nanomedicinal Approaches to Enhance Its Bioactive Functions |
| title_short | Multifunctional Iron Bound Lactoferrin and Nanomedicinal Approaches to Enhance Its Bioactive Functions |
| title_sort | multifunctional iron bound lactoferrin and nanomedicinal approaches to enhance its bioactive functions |
| topic | lactoferrin camel bovine immunity cancer nanoparticles |
| url | http://www.mdpi.com/1420-3049/20/6/9703 |
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