Effect of ASP2151, a Herpesvirus Helicase-Primase Inhibitor, in a Guinea Pig Model of Genital Herpes

Effect of ASP2151, a Herpesvirus Helicase-Primase Inhibitor, in a Guinea Pig Model of Genital Herpes

ASP2151 is a herpesvirus helicase-primase inhibitor with antiviral activity against varicella zoster virus and herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). Here, we examined the potency and efficacy of ASP2151 against HSV in vitro and in vivo. We found that ASP2151 was more potent in inhibiti...

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Bibliographic Details
Main Authors: Toru Kontani, Yasuaki Shimizu, Kenji Sudo, Koji Chono, Kiyomitsu Katsumata, Hiroshi Suzuki
Format: Article
Language:English
Published: MDPI AG 2011-08-01
Series:Molecules
Subjects:
ASP2151
amenamevir
antiviral
HSV
guinea pig
genital herpes
Online Access:http://www.mdpi.com/1420-3049/16/9/7210/

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