Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques

Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques

Abstract Background Increasing evidence for a direct contribution of astrocytes to neuroinflammatory and neurodegenerative processes causing Alzheimer’s disease comes from molecular and functional studies in rodent models. However, these models may not fully recapitulate human disease as human and r...

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Main Authors: Pranav Preman, Julia TCW, Sara Calafate, An Snellinx, Maria Alfonso-Triguero, Nikky Corthout, Sebastian Munck, Dietmar Rudolf Thal, Alison M Goate, Bart De Strooper, Amaia M Arranz
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Molecular Neurodegeneration
Subjects:
Human induced pluripotent stem cells (hiPSCs)
Astrocytes
Chimeric mouse models
Alzheimer’s disease
Amyloid plaques
Apolipoprotein E (APOE)
Online Access:https://doi.org/10.1186/s13024-021-00487-8

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