Association between Inflammatory Markers and Local Recurrence in Patients with Giant Cell Tumor of Bone: A Preliminary Result
Giant cell tumor of bone (GCTB) has a high local recurrence rate of approximately 20%. Systemic inflammatory markers, such as neutrophil-lymphocyte ratio (NLR), modified Glasgow prognostic score (mGPS), prognostic nutritional index (PNI), lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (P...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/30/1/85 |
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| author | Shinji Tsukamoto Andreas F. Mavrogenis Rebeca Angulo Alvarado Matteo Traversari Manabu Akahane Kanya Honoki Yasuhito Tanaka Davide Maria Donati Costantino Errani |
| author_facet | Shinji Tsukamoto Andreas F. Mavrogenis Rebeca Angulo Alvarado Matteo Traversari Manabu Akahane Kanya Honoki Yasuhito Tanaka Davide Maria Donati Costantino Errani |
| author_sort | Shinji Tsukamoto |
| collection | DOAJ |
| description | Giant cell tumor of bone (GCTB) has a high local recurrence rate of approximately 20%. Systemic inflammatory markers, such as neutrophil-lymphocyte ratio (NLR), modified Glasgow prognostic score (mGPS), prognostic nutritional index (PNI), lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (PLR), hemoglobin (Hb), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH), have been reported as prognostic markers in patients with malignant tumors. This study aimed to investigate the correlation between these markers and the local recurrence rate of GCTB. In total, 103 patients with GCTB who underwent surgery at the authors’ institutions between 1993 and 2021 were included. Thirty patients experienced local recurrence. Univariate and multivariate analysis showed that tumor site, preoperative and postoperative denosumab treatment, and surgery were significantly associated with local recurrence-free survival. LDH was associated with local recurrence-free survival on univariate analysis only. NLR, mGPS, PNI, LMR, and PLR score did not correlate with the local recurrence rate. In conclusion, NLR, mGPS, PNI, LMR, PLR score, Hb, ALP, and LDH levels are not correlated with the local recurrence rate of GCTB. However, due to the small number of patients included in this study, this result should be re-evaluated in a multicenter study with a larger sample size. |
| first_indexed | 2024-03-09T13:04:46Z |
| format | Article |
| id | doaj.art-6f6abd0ba91f4651a8d8aee1048f9720 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T13:04:46Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-6f6abd0ba91f4651a8d8aee1048f97202023-11-30T21:50:03ZengMDPI AGCurrent Oncology1198-00521718-77292023-01-013011116113110.3390/curroncol30010085Association between Inflammatory Markers and Local Recurrence in Patients with Giant Cell Tumor of Bone: A Preliminary ResultShinji Tsukamoto0Andreas F. Mavrogenis1Rebeca Angulo Alvarado2Matteo Traversari3Manabu Akahane4Kanya Honoki5Yasuhito Tanaka6Davide Maria Donati7Costantino Errani8Department of Orthopaedic Surgery, Nara Medical University, 840, Shijo-cho, Kashihara 634-8521, Nara, JapanFirst Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine,41 Ventouri Street, 15562 Athens, GreeceDepartment of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, ItalyDepartment of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, ItalyDepartment of Health and Welfare Services, National Institute of Public Health, 2-3-6 Minami, Wako-shi 351-0197, Saitama, JapanDepartment of Orthopaedic Surgery, Nara Medical University, 840, Shijo-cho, Kashihara 634-8521, Nara, JapanDepartment of Orthopaedic Surgery, Nara Medical University, 840, Shijo-cho, Kashihara 634-8521, Nara, JapanDepartment of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, ItalyDepartment of Orthopaedic Oncology, IRCCS Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136 Bologna, ItalyGiant cell tumor of bone (GCTB) has a high local recurrence rate of approximately 20%. Systemic inflammatory markers, such as neutrophil-lymphocyte ratio (NLR), modified Glasgow prognostic score (mGPS), prognostic nutritional index (PNI), lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (PLR), hemoglobin (Hb), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH), have been reported as prognostic markers in patients with malignant tumors. This study aimed to investigate the correlation between these markers and the local recurrence rate of GCTB. In total, 103 patients with GCTB who underwent surgery at the authors’ institutions between 1993 and 2021 were included. Thirty patients experienced local recurrence. Univariate and multivariate analysis showed that tumor site, preoperative and postoperative denosumab treatment, and surgery were significantly associated with local recurrence-free survival. LDH was associated with local recurrence-free survival on univariate analysis only. NLR, mGPS, PNI, LMR, and PLR score did not correlate with the local recurrence rate. In conclusion, NLR, mGPS, PNI, LMR, PLR score, Hb, ALP, and LDH levels are not correlated with the local recurrence rate of GCTB. However, due to the small number of patients included in this study, this result should be re-evaluated in a multicenter study with a larger sample size.https://www.mdpi.com/1718-7729/30/1/85giant cell tumor of boneneutrophil-lymphocyte ratiomodified Glasgow prognostic scoreprognostic nutrient indexlymphocyte-monocyte ratioplatelet-lymphocyte ratio |
| spellingShingle | Shinji Tsukamoto Andreas F. Mavrogenis Rebeca Angulo Alvarado Matteo Traversari Manabu Akahane Kanya Honoki Yasuhito Tanaka Davide Maria Donati Costantino Errani Association between Inflammatory Markers and Local Recurrence in Patients with Giant Cell Tumor of Bone: A Preliminary Result Current Oncology giant cell tumor of bone neutrophil-lymphocyte ratio modified Glasgow prognostic score prognostic nutrient index lymphocyte-monocyte ratio platelet-lymphocyte ratio |
| title | Association between Inflammatory Markers and Local Recurrence in Patients with Giant Cell Tumor of Bone: A Preliminary Result |
| title_full | Association between Inflammatory Markers and Local Recurrence in Patients with Giant Cell Tumor of Bone: A Preliminary Result |
| title_fullStr | Association between Inflammatory Markers and Local Recurrence in Patients with Giant Cell Tumor of Bone: A Preliminary Result |
| title_full_unstemmed | Association between Inflammatory Markers and Local Recurrence in Patients with Giant Cell Tumor of Bone: A Preliminary Result |
| title_short | Association between Inflammatory Markers and Local Recurrence in Patients with Giant Cell Tumor of Bone: A Preliminary Result |
| title_sort | association between inflammatory markers and local recurrence in patients with giant cell tumor of bone a preliminary result |
| topic | giant cell tumor of bone neutrophil-lymphocyte ratio modified Glasgow prognostic score prognostic nutrient index lymphocyte-monocyte ratio platelet-lymphocyte ratio |
| url | https://www.mdpi.com/1718-7729/30/1/85 |
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