Association between Otosclerosis and Rubella in Taiwan: A Nationwide Case-Control Study
Otosclerosis is an early adult-onset disease that is associated with 5–9% and 18–22% of all cases of hearing and conductive hearing loss, respectively, and it is suspected to have a viral etiology. However, the role of viral infection in otosclerosis is still inconclusive. This study aimed to invest...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/5/1761 |
| _version_ | 1797615089845534720 |
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| author | Juen-Haur Hwang Ben-Hui Yu Yi-Chun Chen |
| author_facet | Juen-Haur Hwang Ben-Hui Yu Yi-Chun Chen |
| author_sort | Juen-Haur Hwang |
| collection | DOAJ |
| description | Otosclerosis is an early adult-onset disease that is associated with 5–9% and 18–22% of all cases of hearing and conductive hearing loss, respectively, and it is suspected to have a viral etiology. However, the role of viral infection in otosclerosis is still inconclusive. This study aimed to investigate whether rubella infection was associated with otosclerosis risk. We conducted a nationwide case-control study in Taiwan. Data were retrospectively analyzed from the Taiwan National health Insurance Research Database. Cases consisted of all patients who were aged ≥6 years and had a first-time diagnosis of otosclerosis for the period between 2001 and 2012. The controls were exact matched to cases in a 4:1 ratio by birth year, sex, and must survive in the index year of their matched cases. Adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated by using conditional logistic regression. We examined 647 otosclerosis cases and 2588 controls without otosclerosis. Among the 647 patients with otosclerosis, 241 (37.2%) were male and 406 (62.8%) were female, with most aged between 40 and 59 years, with a mean age of 44.9 years. After adjusting for age and sex, conditional logistic regression revealed that exposure to rubella was not associated with a significant increase in otosclerosis risk (adjusted OR, 2.0; 95% CI, 0.18–22.06, <i>p</i> = 0.57). In conclusion, this study did not show that rubella infection was associated with the risk of otosclerosis in Taiwan. |
| first_indexed | 2024-03-11T07:20:37Z |
| format | Article |
| id | doaj.art-6f6b3b6a704240958dffc0d9a6af0d9f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T07:20:37Z |
| publishDate | 2023-02-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-6f6b3b6a704240958dffc0d9a6af0d9f2023-11-17T07:57:58ZengMDPI AGJournal of Clinical Medicine2077-03832023-02-01125176110.3390/jcm12051761Association between Otosclerosis and Rubella in Taiwan: A Nationwide Case-Control StudyJuen-Haur Hwang0Ben-Hui Yu1Yi-Chun Chen2Department of Otolaryngology Head and Neck Surgery, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 622, TaiwanDepartment of Radiation Oncology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 622, TaiwanSchool of Medicine, Tzu Chi University, Hualien 970, TaiwanOtosclerosis is an early adult-onset disease that is associated with 5–9% and 18–22% of all cases of hearing and conductive hearing loss, respectively, and it is suspected to have a viral etiology. However, the role of viral infection in otosclerosis is still inconclusive. This study aimed to investigate whether rubella infection was associated with otosclerosis risk. We conducted a nationwide case-control study in Taiwan. Data were retrospectively analyzed from the Taiwan National health Insurance Research Database. Cases consisted of all patients who were aged ≥6 years and had a first-time diagnosis of otosclerosis for the period between 2001 and 2012. The controls were exact matched to cases in a 4:1 ratio by birth year, sex, and must survive in the index year of their matched cases. Adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated by using conditional logistic regression. We examined 647 otosclerosis cases and 2588 controls without otosclerosis. Among the 647 patients with otosclerosis, 241 (37.2%) were male and 406 (62.8%) were female, with most aged between 40 and 59 years, with a mean age of 44.9 years. After adjusting for age and sex, conditional logistic regression revealed that exposure to rubella was not associated with a significant increase in otosclerosis risk (adjusted OR, 2.0; 95% CI, 0.18–22.06, <i>p</i> = 0.57). In conclusion, this study did not show that rubella infection was associated with the risk of otosclerosis in Taiwan.https://www.mdpi.com/2077-0383/12/5/1761case-control studyotosclerosisrubellavirus |
| spellingShingle | Juen-Haur Hwang Ben-Hui Yu Yi-Chun Chen Association between Otosclerosis and Rubella in Taiwan: A Nationwide Case-Control Study Journal of Clinical Medicine case-control study otosclerosis rubella virus |
| title | Association between Otosclerosis and Rubella in Taiwan: A Nationwide Case-Control Study |
| title_full | Association between Otosclerosis and Rubella in Taiwan: A Nationwide Case-Control Study |
| title_fullStr | Association between Otosclerosis and Rubella in Taiwan: A Nationwide Case-Control Study |
| title_full_unstemmed | Association between Otosclerosis and Rubella in Taiwan: A Nationwide Case-Control Study |
| title_short | Association between Otosclerosis and Rubella in Taiwan: A Nationwide Case-Control Study |
| title_sort | association between otosclerosis and rubella in taiwan a nationwide case control study |
| topic | case-control study otosclerosis rubella virus |
| url | https://www.mdpi.com/2077-0383/12/5/1761 |
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