The Role of <i>BRCA1/2</i>-Mutated Tumor Microenvironment in Breast Cancer

The Role of <i>BRCA1/2</i>-Mutated Tumor Microenvironment in Breast Cancer

Taking into account the factors of high incidence rate, prevalence and mortality, breast cancer represents a crucial social and economic burden. Most cases of breast cancer develop as a consequence of somatic mutations accumulating in mammary epithelial cells throughout lifetime and approximately 5–...

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Bibliographic Details
Main Authors: Svetlana Miklikova, Lenka Trnkova, Jana Plava, Martin Bohac, Marcela Kuniakova, Marina Cihova
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
breast cancer
tumor microenvironment
<i>BRCA1/2</i> mutations
stromal cells
epithelial-to-mesenchymal transition
angiogenesis
Online Access:https://www.mdpi.com/2072-6694/13/3/575

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