Single nuclei RNA sequencing of the rat AP and NTS following GDF15 treatment

Single nuclei RNA sequencing of the rat AP and NTS following GDF15 treatment

Objective: Growth differentiation factor 15 (GDF15) is known to play a role in feeding, nausea, and body weight, with action through the GFRAL-RET receptor complex in the area postrema (AP) and nucleus tractus solitarius (NTS). To further elucidate the underlying cell type-specific molecular mechani...

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Bibliographic Details
Main Authors: Benjamin C. Reiner, Richard C. Crist, Tito Borner, Robert P. Doyle, Matthew R. Hayes, Bart C. De Jonghe
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Molecular Metabolism
Subjects:
Area postrema
Nucleus of the solitary tract
GDF15
GFRAL
RET
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877821002805

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