Profiles of Elderly Patients with Obesity Hypoventilation Syndrome in Martinique: A Single-Center Study
Obesity hypoventilation syndrome (OHS) is a form of chronic respiratory insufficiency related to obesity that affects young and old people. Age appears to be associated with poorer response to treatment by nighttime ventilation. This study aimed to describe the characteristics of elderly subjects (&...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/7/1089 |
| _version_ | 1797588701173252096 |
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| author | Moustapha Agossou Nadine Simo-Tabué Marion Dufeal Bérénice Awanou Mathilde Provost Ketty Smith Elena Badaran Adel Zouzou Nelly Ahouansou Maturin Tabué-Teguo Moustapha Dramé |
| author_facet | Moustapha Agossou Nadine Simo-Tabué Marion Dufeal Bérénice Awanou Mathilde Provost Ketty Smith Elena Badaran Adel Zouzou Nelly Ahouansou Maturin Tabué-Teguo Moustapha Dramé |
| author_sort | Moustapha Agossou |
| collection | DOAJ |
| description | Obesity hypoventilation syndrome (OHS) is a form of chronic respiratory insufficiency related to obesity that affects young and old people. Age appears to be associated with poorer response to treatment by nighttime ventilation. This study aimed to describe the characteristics of elderly subjects (>65 years) with OHS compared to younger patients, with a view to adapting therapy in older individuals. We conducted a retrospective study comparing socio-demographic, clinical, functional characteristics as well as treatment and outcomes between young (<65 years) and older (65 years and older) individuals with OHS at the University Hospital of Martinique. We included 143 patients (114 women), of whom 82 were 65 years or older (57%). Charlson index was higher in the older group. Patients in ≥65 years group were less frequently obese, but more frequently had diabetes mellitus, cardiac arrythmia and arterial hypertension compared to younger patients. There was no difference in the circumstances of diagnosis or arterial blood gas at diagnosis. At follow up, partial pressure of carbon dioxide (pCO<sub>2</sub>) was higher in ≥65 years group. Despite comparable NIV settings, apart from lower expiratory positive airway pressure (EPAP) with higher apnea-hypopnea index (AHI), patients in the ≥65-year-old group remained more frequently hypercapnic. In conclusion, over half (57%) of patients with OHS in our cohort were aged over 65 years. Older patients developed OHS at lower BMI levels than their younger counterparts, and more frequently, had comorbidities such as diabetes, hypertension and cardiac arrhythmia. Increased Charlson index, lower BMI and female sex were independent factors associated with OHS in the elderly. |
| first_indexed | 2024-03-11T00:55:44Z |
| format | Article |
| id | doaj.art-6f6f711525b54f5fb801aefbcc172373 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T00:55:44Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-6f6f711525b54f5fb801aefbcc1723732023-11-18T20:03:25ZengMDPI AGJournal of Personalized Medicine2075-44262023-06-01137108910.3390/jpm13071089Profiles of Elderly Patients with Obesity Hypoventilation Syndrome in Martinique: A Single-Center StudyMoustapha Agossou0Nadine Simo-Tabué1Marion Dufeal2Bérénice Awanou3Mathilde Provost4Ketty Smith5Elena Badaran6Adel Zouzou7Nelly Ahouansou8Maturin Tabué-Teguo9Moustapha Dramé10Department of Respiratory Medicine, CHU of Martinique, 97261 Fort-de-France, FranceDepartment of Geriatrics, CHU of Martinique, 97261 Fort-de-France, FranceDepartment of Respiratory Medicine, CHU of Martinique, 97261 Fort-de-France, FranceDepartment of Respiratory Medicine, CHU of Martinique, 97261 Fort-de-France, FranceDepartment of Respiratory Medicine, CHU of Martinique, 97261 Fort-de-France, FranceDepartment of Respiratory Medicine, CHU of Martinique, 97261 Fort-de-France, FranceDepartment of Respiratory Medicine, CHU of Martinique, 97261 Fort-de-France, FranceDepartment of Respiratory Medicine, CHU of Martinique, 97261 Fort-de-France, FranceDepartment of Respiratory Medicine, CHU of Martinique, 97261 Fort-de-France, FranceDepartment of Geriatrics, CHU of Martinique, 97261 Fort-de-France, FranceEpiCliV Research Unit, Faculty of Medicine, University of the French West Indies, 97261 Fort-de-France, FranceObesity hypoventilation syndrome (OHS) is a form of chronic respiratory insufficiency related to obesity that affects young and old people. Age appears to be associated with poorer response to treatment by nighttime ventilation. This study aimed to describe the characteristics of elderly subjects (>65 years) with OHS compared to younger patients, with a view to adapting therapy in older individuals. We conducted a retrospective study comparing socio-demographic, clinical, functional characteristics as well as treatment and outcomes between young (<65 years) and older (65 years and older) individuals with OHS at the University Hospital of Martinique. We included 143 patients (114 women), of whom 82 were 65 years or older (57%). Charlson index was higher in the older group. Patients in ≥65 years group were less frequently obese, but more frequently had diabetes mellitus, cardiac arrythmia and arterial hypertension compared to younger patients. There was no difference in the circumstances of diagnosis or arterial blood gas at diagnosis. At follow up, partial pressure of carbon dioxide (pCO<sub>2</sub>) was higher in ≥65 years group. Despite comparable NIV settings, apart from lower expiratory positive airway pressure (EPAP) with higher apnea-hypopnea index (AHI), patients in the ≥65-year-old group remained more frequently hypercapnic. In conclusion, over half (57%) of patients with OHS in our cohort were aged over 65 years. Older patients developed OHS at lower BMI levels than their younger counterparts, and more frequently, had comorbidities such as diabetes, hypertension and cardiac arrhythmia. Increased Charlson index, lower BMI and female sex were independent factors associated with OHS in the elderly.https://www.mdpi.com/2075-4426/13/7/1089elderlyobesity hypoventilation syndromechronic respiratory failurechronic hypercapniaAfro-Caribbean descent |
| spellingShingle | Moustapha Agossou Nadine Simo-Tabué Marion Dufeal Bérénice Awanou Mathilde Provost Ketty Smith Elena Badaran Adel Zouzou Nelly Ahouansou Maturin Tabué-Teguo Moustapha Dramé Profiles of Elderly Patients with Obesity Hypoventilation Syndrome in Martinique: A Single-Center Study Journal of Personalized Medicine elderly obesity hypoventilation syndrome chronic respiratory failure chronic hypercapnia Afro-Caribbean descent |
| title | Profiles of Elderly Patients with Obesity Hypoventilation Syndrome in Martinique: A Single-Center Study |
| title_full | Profiles of Elderly Patients with Obesity Hypoventilation Syndrome in Martinique: A Single-Center Study |
| title_fullStr | Profiles of Elderly Patients with Obesity Hypoventilation Syndrome in Martinique: A Single-Center Study |
| title_full_unstemmed | Profiles of Elderly Patients with Obesity Hypoventilation Syndrome in Martinique: A Single-Center Study |
| title_short | Profiles of Elderly Patients with Obesity Hypoventilation Syndrome in Martinique: A Single-Center Study |
| title_sort | profiles of elderly patients with obesity hypoventilation syndrome in martinique a single center study |
| topic | elderly obesity hypoventilation syndrome chronic respiratory failure chronic hypercapnia Afro-Caribbean descent |
| url | https://www.mdpi.com/2075-4426/13/7/1089 |
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