Giant cell tumor of the talus: A case report
Giant cell tumor is a benign primary bone neoplasm which most often occurs in a periarticular location. Involvement of the bones of the foot and ankle is rare, and there have been a limited number of previous case reports involving the talus. Here we report a case of giant cell tumor of the talus, w...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-07-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043320300960 |
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| author | Dana Galvan, MD, MPH Carola Mullins, MD Ellen Dudrey, MD Lisa Kafchinski, MD Shaked Laks, MD |
| author_facet | Dana Galvan, MD, MPH Carola Mullins, MD Ellen Dudrey, MD Lisa Kafchinski, MD Shaked Laks, MD |
| author_sort | Dana Galvan, MD, MPH |
| collection | DOAJ |
| description | Giant cell tumor is a benign primary bone neoplasm which most often occurs in a periarticular location. Involvement of the bones of the foot and ankle is rare, and there have been a limited number of previous case reports involving the talus. Here we report a case of giant cell tumor of the talus, which was initially radiographically occult in a 43-year-old female, with emphasis on MRI imaging characteristics. The patient underwent surgical excision and curettage. Histological examination revealed the presence of spindle cells admixed with giant cells, confirming GCT. We further provide an overview of the radiological findings of GCT.Giant cell tumor is a benign bone neoplasm of mesenchymal origin, identified by multinucleated giant cells [1]. GCT is locally aggressive and can destroy adjacent bone and articulations. The most commonly affected bones are the distal femur, proximal tibia, and distal radius, with an epiphyseal predominance in 90% of cases [2]. Presentations are mostly mono-ostotic, however multicentricity may occur in younger patients [3]. Very few cases have been reported in the bones of the feet, an incidence of 1%-2% have been previously reported [4].GCT is seen between ages 20 and 40 years, with a 56% predominance in females [3]. Although benign, 1%-9% cases may “metastasize” to the lungs. The initial treatment is surgical removal, either en bloc, or more commonly intralesional curettage and the use of adjuvants. Even after resection, GCT has a high recurrence rate [2]. The trigger for GCT is currently unknown. However, a majority of cases have cytogenetic abnormalities of telomeric associations (tas). Involvement of the RANK pathway is also believed to contribute to the pathogenesis of GCT [2]. |
| first_indexed | 2024-12-21T15:32:27Z |
| format | Article |
| id | doaj.art-6f703010a51740ad80b4f397eb6517da |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-12-21T15:32:27Z |
| publishDate | 2020-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-6f703010a51740ad80b4f397eb6517da2022-12-21T18:58:43ZengElsevierRadiology Case Reports1930-04332020-07-01157825831Giant cell tumor of the talus: A case reportDana Galvan, MD, MPH0Carola Mullins, MD1Ellen Dudrey, MD2Lisa Kafchinski, MD3Shaked Laks, MD4Transitional Year Department, University of Rio Grande ValleyDepartment of Radiology, Texas Tech University Health Sciences Center El Paso, 5001 El Paso Drive, CSB-A02, El Paso, TX 79905; Corresponding author.Department of Pathology, Texas Tech University Health Sciences Center El Paso, El Paso, TXDepartment of Orthopedic Surgery, Texas Tech University Health Sciences Center El Paso, El Paso, TXDepartment of Radiology, Texas Tech University Health Sciences Center El Paso, 5001 El Paso Drive, CSB-A02, El Paso, TX 79905Giant cell tumor is a benign primary bone neoplasm which most often occurs in a periarticular location. Involvement of the bones of the foot and ankle is rare, and there have been a limited number of previous case reports involving the talus. Here we report a case of giant cell tumor of the talus, which was initially radiographically occult in a 43-year-old female, with emphasis on MRI imaging characteristics. The patient underwent surgical excision and curettage. Histological examination revealed the presence of spindle cells admixed with giant cells, confirming GCT. We further provide an overview of the radiological findings of GCT.Giant cell tumor is a benign bone neoplasm of mesenchymal origin, identified by multinucleated giant cells [1]. GCT is locally aggressive and can destroy adjacent bone and articulations. The most commonly affected bones are the distal femur, proximal tibia, and distal radius, with an epiphyseal predominance in 90% of cases [2]. Presentations are mostly mono-ostotic, however multicentricity may occur in younger patients [3]. Very few cases have been reported in the bones of the feet, an incidence of 1%-2% have been previously reported [4].GCT is seen between ages 20 and 40 years, with a 56% predominance in females [3]. Although benign, 1%-9% cases may “metastasize” to the lungs. The initial treatment is surgical removal, either en bloc, or more commonly intralesional curettage and the use of adjuvants. Even after resection, GCT has a high recurrence rate [2]. The trigger for GCT is currently unknown. However, a majority of cases have cytogenetic abnormalities of telomeric associations (tas). Involvement of the RANK pathway is also believed to contribute to the pathogenesis of GCT [2].http://www.sciencedirect.com/science/article/pii/S1930043320300960Giant Cell TumorGCTTalus |
| spellingShingle | Dana Galvan, MD, MPH Carola Mullins, MD Ellen Dudrey, MD Lisa Kafchinski, MD Shaked Laks, MD Giant cell tumor of the talus: A case report Radiology Case Reports Giant Cell Tumor GCT Talus |
| title | Giant cell tumor of the talus: A case report |
| title_full | Giant cell tumor of the talus: A case report |
| title_fullStr | Giant cell tumor of the talus: A case report |
| title_full_unstemmed | Giant cell tumor of the talus: A case report |
| title_short | Giant cell tumor of the talus: A case report |
| title_sort | giant cell tumor of the talus a case report |
| topic | Giant Cell Tumor GCT Talus |
| url | http://www.sciencedirect.com/science/article/pii/S1930043320300960 |
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