The extract of peanut shell enhances neurite outgrowth of neuronal cells: Recycling of agricultural waste for development of nutraceutical products
Peanut shell is an agricultural waste having an urgent need to be utilized. The ethanolic extract of peanut shell extract, named as PSE, having enrichment of flavonoids with neurotrophic function, can develop as dietary supplements. In cultured PC12 cells, SH-SY5Y cells and rat primary neurons, the...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622000937 |
| _version_ | 1818773107124469760 |
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| author | Alex Xiong Gao Jian Xiao Tracy Chen-Xi Xia Tina Ting-Xia Dong Karl Wah-Keung Tsim |
| author_facet | Alex Xiong Gao Jian Xiao Tracy Chen-Xi Xia Tina Ting-Xia Dong Karl Wah-Keung Tsim |
| author_sort | Alex Xiong Gao |
| collection | DOAJ |
| description | Peanut shell is an agricultural waste having an urgent need to be utilized. The ethanolic extract of peanut shell extract, named as PSE, having enrichment of flavonoids with neurotrophic function, can develop as dietary supplements. In cultured PC12 cells, SH-SY5Y cells and rat primary neurons, the application of PSE increased the proportion of differentiated cells. In parallel, the neuronal differentiation markers, i.e. neurofilaments, were increased at both mRNA and protein levels under PSE treatment. In revealing the signaling cascade, extracellular signal-regulated kinase1/2 (ERK1/2) and protein kinase B (Akt) were activated by PSE. The PSE-induced cell differentiation was blocked by the kinase inhibitors, U0126 and LY294002. The phytochemicals within PSE, e.g. luteolin, eriodictyol and 5,7-dihydroxychromone, induced transcription of neurofilaments in cultures, which in combination could partially account for the neurotrophic functions of PSE. This result supports the waste product from peanut production could be recycled in developing high value nutraceutical products. |
| first_indexed | 2024-12-18T10:19:59Z |
| format | Article |
| id | doaj.art-6f70c70e14f1490c85edd230934983d6 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-18T10:19:59Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-6f70c70e14f1490c85edd230934983d62022-12-21T21:11:10ZengElsevierJournal of Functional Foods1756-46462022-04-0191105023The extract of peanut shell enhances neurite outgrowth of neuronal cells: Recycling of agricultural waste for development of nutraceutical productsAlex Xiong Gao0Jian Xiao1Tracy Chen-Xi Xia2Tina Ting-Xia Dong3Karl Wah-Keung Tsim4Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518000, China; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, ChinaDivision of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China; Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, Shaanxi 721013, ChinaShenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518000, China; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, ChinaShenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518000, China; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, ChinaShenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518000, China; Division of Life Science and Center for Chinese Medicine, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China; Corresponding author at: Shenzhen Key Laboratory of Edible and Medicinal Bioresources, HKUST Shenzhen Research Institute, Hi-Tech Park, Nanshan, Shenzhen 518000, China.Peanut shell is an agricultural waste having an urgent need to be utilized. The ethanolic extract of peanut shell extract, named as PSE, having enrichment of flavonoids with neurotrophic function, can develop as dietary supplements. In cultured PC12 cells, SH-SY5Y cells and rat primary neurons, the application of PSE increased the proportion of differentiated cells. In parallel, the neuronal differentiation markers, i.e. neurofilaments, were increased at both mRNA and protein levels under PSE treatment. In revealing the signaling cascade, extracellular signal-regulated kinase1/2 (ERK1/2) and protein kinase B (Akt) were activated by PSE. The PSE-induced cell differentiation was blocked by the kinase inhibitors, U0126 and LY294002. The phytochemicals within PSE, e.g. luteolin, eriodictyol and 5,7-dihydroxychromone, induced transcription of neurofilaments in cultures, which in combination could partially account for the neurotrophic functions of PSE. This result supports the waste product from peanut production could be recycled in developing high value nutraceutical products.http://www.sciencedirect.com/science/article/pii/S1756464622000937Agricultural wastePeanut shellFlavonoidLuteolinNeurite outgrowthNeurotrophic factor |
| spellingShingle | Alex Xiong Gao Jian Xiao Tracy Chen-Xi Xia Tina Ting-Xia Dong Karl Wah-Keung Tsim The extract of peanut shell enhances neurite outgrowth of neuronal cells: Recycling of agricultural waste for development of nutraceutical products Journal of Functional Foods Agricultural waste Peanut shell Flavonoid Luteolin Neurite outgrowth Neurotrophic factor |
| title | The extract of peanut shell enhances neurite outgrowth of neuronal cells: Recycling of agricultural waste for development of nutraceutical products |
| title_full | The extract of peanut shell enhances neurite outgrowth of neuronal cells: Recycling of agricultural waste for development of nutraceutical products |
| title_fullStr | The extract of peanut shell enhances neurite outgrowth of neuronal cells: Recycling of agricultural waste for development of nutraceutical products |
| title_full_unstemmed | The extract of peanut shell enhances neurite outgrowth of neuronal cells: Recycling of agricultural waste for development of nutraceutical products |
| title_short | The extract of peanut shell enhances neurite outgrowth of neuronal cells: Recycling of agricultural waste for development of nutraceutical products |
| title_sort | extract of peanut shell enhances neurite outgrowth of neuronal cells recycling of agricultural waste for development of nutraceutical products |
| topic | Agricultural waste Peanut shell Flavonoid Luteolin Neurite outgrowth Neurotrophic factor |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622000937 |
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