Cutaneous lesions sensory impairment recovery and nerve regeneration in leprosy patients
It is important to understand the mechanisms that enable peripheral neurons to regenerate after nerve injury in order to identify methods of improving this regeneration. Therefore, we studied nerve regeneration and sensory impairment recovery in the cutaneous lesions of leprosy patients (LPs) before...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2012-12-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000900012&lng=en&tlng=en |
| _version_ | 1797758441094119424 |
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| author | Ximena Illarramendi Emanuel Rangel Alice Machado Miranda Ana Claudia Ribeiro de Castro Giselle de Oliveira Magalhães Sérgio Luiz Gomes Antunes |
| author_facet | Ximena Illarramendi Emanuel Rangel Alice Machado Miranda Ana Claudia Ribeiro de Castro Giselle de Oliveira Magalhães Sérgio Luiz Gomes Antunes |
| author_sort | Ximena Illarramendi |
| collection | DOAJ |
| description | It is important to understand the mechanisms that enable peripheral neurons to regenerate after nerve injury in order to identify methods of improving this regeneration. Therefore, we studied nerve regeneration and sensory impairment recovery in the cutaneous lesions of leprosy patients (LPs) before and after treatment with multidrug therapy (MDT). The skin lesion sensory test results were compared to the histopathological and immunohistochemical protein gene product (PGP) 9.5 and the p75 nerve growth factor receptors (NGFr) findings. The cutaneous neural occupation ratio (CNOR) was evaluated for both neural markers. Thermal and pain sensations were the most frequently affected functions at the first visit and the most frequently recovered functions after MDT. The presence of a high cutaneous nerve damage index did not prevent the recovery of any type of sensory function. The CNOR was calculated for each biopsy, according to the presence of PGP and NGFr-immunostained fibres and it was not significantly different before or after the MDT. We observed a variable influence of MDT in the recovery from sensory impairment in the cutaneous lesions of LPs. Nociception and cold thermosensation were the most recovered sensations. The recovery of sensation in the skin lesions appeared to be associated with subsiding inflammation rather than with the regenerative activity of nerve fibres. |
| first_indexed | 2024-03-12T18:30:01Z |
| format | Article |
| id | doaj.art-6f727cb4e7ef49ca833cad5d8c2f16e5 |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:30:01Z |
| publishDate | 2012-12-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-6f727cb4e7ef49ca833cad5d8c2f16e52023-08-02T08:19:30ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602012-12-01107suppl 1687310.1590/S0074-02762012000900012S0074-02762012000900012Cutaneous lesions sensory impairment recovery and nerve regeneration in leprosy patientsXimena Illarramendi0Emanuel Rangel1Alice Machado Miranda2Ana Claudia Ribeiro de Castro3Giselle de Oliveira Magalhães4Sérgio Luiz Gomes Antunes5Fundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzFundação Oswaldo CruzIt is important to understand the mechanisms that enable peripheral neurons to regenerate after nerve injury in order to identify methods of improving this regeneration. Therefore, we studied nerve regeneration and sensory impairment recovery in the cutaneous lesions of leprosy patients (LPs) before and after treatment with multidrug therapy (MDT). The skin lesion sensory test results were compared to the histopathological and immunohistochemical protein gene product (PGP) 9.5 and the p75 nerve growth factor receptors (NGFr) findings. The cutaneous neural occupation ratio (CNOR) was evaluated for both neural markers. Thermal and pain sensations were the most frequently affected functions at the first visit and the most frequently recovered functions after MDT. The presence of a high cutaneous nerve damage index did not prevent the recovery of any type of sensory function. The CNOR was calculated for each biopsy, according to the presence of PGP and NGFr-immunostained fibres and it was not significantly different before or after the MDT. We observed a variable influence of MDT in the recovery from sensory impairment in the cutaneous lesions of LPs. Nociception and cold thermosensation were the most recovered sensations. The recovery of sensation in the skin lesions appeared to be associated with subsiding inflammation rather than with the regenerative activity of nerve fibres.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000900012&lng=en&tlng=enleprosycutaneous nerve fibrenerve regenerationPGP 9.5nerve growth factor receptorimmunohistochemistry |
| spellingShingle | Ximena Illarramendi Emanuel Rangel Alice Machado Miranda Ana Claudia Ribeiro de Castro Giselle de Oliveira Magalhães Sérgio Luiz Gomes Antunes Cutaneous lesions sensory impairment recovery and nerve regeneration in leprosy patients Memorias do Instituto Oswaldo Cruz leprosy cutaneous nerve fibre nerve regeneration PGP 9.5 nerve growth factor receptor immunohistochemistry |
| title | Cutaneous lesions sensory impairment recovery and nerve regeneration in leprosy patients |
| title_full | Cutaneous lesions sensory impairment recovery and nerve regeneration in leprosy patients |
| title_fullStr | Cutaneous lesions sensory impairment recovery and nerve regeneration in leprosy patients |
| title_full_unstemmed | Cutaneous lesions sensory impairment recovery and nerve regeneration in leprosy patients |
| title_short | Cutaneous lesions sensory impairment recovery and nerve regeneration in leprosy patients |
| title_sort | cutaneous lesions sensory impairment recovery and nerve regeneration in leprosy patients |
| topic | leprosy cutaneous nerve fibre nerve regeneration PGP 9.5 nerve growth factor receptor immunohistochemistry |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000900012&lng=en&tlng=en |
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