Association between sarcopenia and frailty in elderly patients with chronic kidney disease
Abstract Background Frailty and sarcopenia are prevalent in chronic kidney disease (CKD) populations and could increase the risk for adverse health outcomes. Few studies assess the correlation between frailty, sarcopenia and CKD in non‐dialysis patients. Therefore, this study aimed to determine frai...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Journal of Cachexia, Sarcopenia and Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jcsm.13275 |
| _version_ | 1827267284637319168 |
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| author | Che Wang Xinru Guo Xieguanxuan Xu Shuang Liang Wenling Wang Fanglei Zhu Siyang Wang Jie Wu Li Zhang Xuefeng Sun Xiangmei Chen Guangyan Cai The Chinese observational prospective study of ageing population with chronic kidney disease (C‐OPTION) |
| author_facet | Che Wang Xinru Guo Xieguanxuan Xu Shuang Liang Wenling Wang Fanglei Zhu Siyang Wang Jie Wu Li Zhang Xuefeng Sun Xiangmei Chen Guangyan Cai The Chinese observational prospective study of ageing population with chronic kidney disease (C‐OPTION) |
| author_sort | Che Wang |
| collection | DOAJ |
| description | Abstract Background Frailty and sarcopenia are prevalent in chronic kidney disease (CKD) populations and could increase the risk for adverse health outcomes. Few studies assess the correlation between frailty, sarcopenia and CKD in non‐dialysis patients. Therefore, this study aimed to determine frailty‐associated factors in elderly CKD stage I–IV patients, expected to early identify and intervene in the frailty of elderly CKD patients. Methods A total of 774 elderly CKD I–IV patients (>60 years of age) recruited from 29 clinical centers in China between March 2017 and September 2019 were included in this study. We established a Frailty Index (FI) model to evaluate frailty risk and verified the distributional property of FI in the study population. Sarcopenia was defined according to the criteria of the Asian Working Group for Sarcopenia 2019. Multinomial logistic regression analysis was used to assess the associated factors for frailty. Results Seven hundred seventy‐four patients (median age 67 years, 66.0% males) were included in this analysis, with a median estimated glomerular filtration rate of 52.8 mL/min/1.73 m2. The prevalence of sarcopenia was 30.6%. The FI exhibited a right‐skewed distribution. The age‐related slope of FI was 1.4% per year on a logarithmic scale (r2 = 0.706, 95% CI 0.9, 1.8, P < 0.001). The upper limit of FI was around 0.43. The FI was related to mortality (HR = 1.06, 95% CI 1.00, 1.12, P = 0.041). Multivariate multinomial logistic regression analysis showed that sarcopenia, advanced age, CKD stage II–IV, low level of serum albumin and increased waist–hip ratio were significantly associated with high FI status, while advanced age and CKD stage III–IV were significantly associated with for median FI status. Moreover, the results from the subgroup were consistent with the leading results. Conclusions Sarcopenia was independently associated with an increased risk for frailty in elderly CKD I‐IV patients. Patients with sarcopenia, advanced age, high CKD stage, high waist–hip ratio and low serum albumin level should be assessed for frailty. |
| first_indexed | 2024-03-12T17:36:45Z |
| format | Article |
| id | doaj.art-6f746dad3a654635bcd959e8dac35c65 |
| institution | Directory Open Access Journal |
| issn | 2190-5991 2190-6009 |
| language | English |
| last_indexed | 2025-03-22T04:31:18Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Cachexia, Sarcopenia and Muscle |
| spelling | doaj.art-6f746dad3a654635bcd959e8dac35c652024-04-28T03:34:38ZengWileyJournal of Cachexia, Sarcopenia and Muscle2190-59912190-60092023-08-011441855186410.1002/jcsm.13275Association between sarcopenia and frailty in elderly patients with chronic kidney diseaseChe Wang0Xinru Guo1Xieguanxuan Xu2Shuang Liang3Wenling Wang4Fanglei Zhu5Siyang Wang6Jie Wu7Li Zhang8Xuefeng Sun9Xiangmei Chen10Guangyan Cai11The Chinese observational prospective study of ageing population with chronic kidney disease (C‐OPTION)Department of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing ChinaDepartment of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing ChinaDepartment of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing ChinaDepartment of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing ChinaDepartment of Nephrology The Fifth Medical Center of Chinese PLA General Hospital Beijing ChinaDepartment of Nephrology Fuxing Hospital Affiliate to Capital University of Medical Sciences Beijing ChinaDepartment of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing ChinaDepartment of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing ChinaDepartment of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing ChinaDepartment of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing ChinaDepartment of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing ChinaDepartment of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Beijing ChinaAbstract Background Frailty and sarcopenia are prevalent in chronic kidney disease (CKD) populations and could increase the risk for adverse health outcomes. Few studies assess the correlation between frailty, sarcopenia and CKD in non‐dialysis patients. Therefore, this study aimed to determine frailty‐associated factors in elderly CKD stage I–IV patients, expected to early identify and intervene in the frailty of elderly CKD patients. Methods A total of 774 elderly CKD I–IV patients (>60 years of age) recruited from 29 clinical centers in China between March 2017 and September 2019 were included in this study. We established a Frailty Index (FI) model to evaluate frailty risk and verified the distributional property of FI in the study population. Sarcopenia was defined according to the criteria of the Asian Working Group for Sarcopenia 2019. Multinomial logistic regression analysis was used to assess the associated factors for frailty. Results Seven hundred seventy‐four patients (median age 67 years, 66.0% males) were included in this analysis, with a median estimated glomerular filtration rate of 52.8 mL/min/1.73 m2. The prevalence of sarcopenia was 30.6%. The FI exhibited a right‐skewed distribution. The age‐related slope of FI was 1.4% per year on a logarithmic scale (r2 = 0.706, 95% CI 0.9, 1.8, P < 0.001). The upper limit of FI was around 0.43. The FI was related to mortality (HR = 1.06, 95% CI 1.00, 1.12, P = 0.041). Multivariate multinomial logistic regression analysis showed that sarcopenia, advanced age, CKD stage II–IV, low level of serum albumin and increased waist–hip ratio were significantly associated with high FI status, while advanced age and CKD stage III–IV were significantly associated with for median FI status. Moreover, the results from the subgroup were consistent with the leading results. Conclusions Sarcopenia was independently associated with an increased risk for frailty in elderly CKD I‐IV patients. Patients with sarcopenia, advanced age, high CKD stage, high waist–hip ratio and low serum albumin level should be assessed for frailty.https://doi.org/10.1002/jcsm.13275FrailtyFrailty IndexSarcopeniaChronic Kidney DiseaseElderly |
| spellingShingle | Che Wang Xinru Guo Xieguanxuan Xu Shuang Liang Wenling Wang Fanglei Zhu Siyang Wang Jie Wu Li Zhang Xuefeng Sun Xiangmei Chen Guangyan Cai The Chinese observational prospective study of ageing population with chronic kidney disease (C‐OPTION) Association between sarcopenia and frailty in elderly patients with chronic kidney disease Journal of Cachexia, Sarcopenia and Muscle Frailty Frailty Index Sarcopenia Chronic Kidney Disease Elderly |
| title | Association between sarcopenia and frailty in elderly patients with chronic kidney disease |
| title_full | Association between sarcopenia and frailty in elderly patients with chronic kidney disease |
| title_fullStr | Association between sarcopenia and frailty in elderly patients with chronic kidney disease |
| title_full_unstemmed | Association between sarcopenia and frailty in elderly patients with chronic kidney disease |
| title_short | Association between sarcopenia and frailty in elderly patients with chronic kidney disease |
| title_sort | association between sarcopenia and frailty in elderly patients with chronic kidney disease |
| topic | Frailty Frailty Index Sarcopenia Chronic Kidney Disease Elderly |
| url | https://doi.org/10.1002/jcsm.13275 |
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