Positive rate of malignant cells in endometrial cytology samples of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer patients: A systematic review and meta-analysis
To estimate the feasibility of diagnosing ovarian cancer, fallopian tube cancer, and primary peritoneal cancer through endometrial cytology, we performed a systematic review and meta-analysis to calculate the pooled positive rate of malignant cells in endometrial cytology samples. We queried PubMed,...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Cytology |
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| Online Access: | http://www.jcytol.org/article.asp?issn=0970-9371;year=2023;volume=40;issue=2;spage=51;epage=57;aulast=Wang |
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| author | Tiantian Wang Yadi Bin Lanbo Zhao Qiling Li |
| author_facet | Tiantian Wang Yadi Bin Lanbo Zhao Qiling Li |
| author_sort | Tiantian Wang |
| collection | DOAJ |
| description | To estimate the feasibility of diagnosing ovarian cancer, fallopian tube cancer, and primary peritoneal cancer through endometrial cytology, we performed a systematic review and meta-analysis to calculate the pooled positive rate of malignant cells in endometrial cytology samples. We queried PubMed, EMBASE, Medline, and Cochrane Central Register of Controlled Trails from inception to November 12, 2020 for studies estimating positive rates of malignant cells in endometrial cytology samples from patients with ovarian cancer, fallopian tube cancer, and primary peritoneal cancer. The positive rates of the included studies were calculated as pooled positive rate through meta-analyses of proportion. Subgroup analysis based on different sampling methods was conducted. Seven retrospective studies involving 975 patients were included. Pooled positive rate of malignant cells in endometrial cytology specimens of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer patients was 23% (95% CI: 16% - 34%). Statistical heterogeneity between the included studies was considerable (I2 = 89%, P < 0.01). The pooled positive rates of the group of brushes and the group of aspiration smears were 13% (95% CI: 10% - 17%, I2 = 0, P = 0.45) and 33% (95% CI: 25% - 42%, I2 = 80%, P < 0.01), respectively. Although endometrial cytology is not an ideal diagnostic tool for ovarian cancer, fallopian tube cancer, and primary peritoneal cancer, it is a convenient, painless, and easy-to-implement adjunct to other tools. Sampling method is one of the factors that affect the detection rate. |
| first_indexed | 2024-03-12T22:13:44Z |
| format | Article |
| id | doaj.art-6f748b33f02046c28363dfc60e0885d2 |
| institution | Directory Open Access Journal |
| issn | 0970-9371 |
| language | English |
| last_indexed | 2024-03-12T22:13:44Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cytology |
| spelling | doaj.art-6f748b33f02046c28363dfc60e0885d22023-07-23T11:26:17ZengWolters Kluwer Medknow PublicationsJournal of Cytology0970-93712023-01-01402515710.4103/joc.joc_49_22Positive rate of malignant cells in endometrial cytology samples of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer patients: A systematic review and meta-analysisTiantian WangYadi BinLanbo ZhaoQiling LiTo estimate the feasibility of diagnosing ovarian cancer, fallopian tube cancer, and primary peritoneal cancer through endometrial cytology, we performed a systematic review and meta-analysis to calculate the pooled positive rate of malignant cells in endometrial cytology samples. We queried PubMed, EMBASE, Medline, and Cochrane Central Register of Controlled Trails from inception to November 12, 2020 for studies estimating positive rates of malignant cells in endometrial cytology samples from patients with ovarian cancer, fallopian tube cancer, and primary peritoneal cancer. The positive rates of the included studies were calculated as pooled positive rate through meta-analyses of proportion. Subgroup analysis based on different sampling methods was conducted. Seven retrospective studies involving 975 patients were included. Pooled positive rate of malignant cells in endometrial cytology specimens of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer patients was 23% (95% CI: 16% - 34%). Statistical heterogeneity between the included studies was considerable (I2 = 89%, P < 0.01). The pooled positive rates of the group of brushes and the group of aspiration smears were 13% (95% CI: 10% - 17%, I2 = 0, P = 0.45) and 33% (95% CI: 25% - 42%, I2 = 80%, P < 0.01), respectively. Although endometrial cytology is not an ideal diagnostic tool for ovarian cancer, fallopian tube cancer, and primary peritoneal cancer, it is a convenient, painless, and easy-to-implement adjunct to other tools. Sampling method is one of the factors that affect the detection rate.http://www.jcytol.org/article.asp?issn=0970-9371;year=2023;volume=40;issue=2;spage=51;epage=57;aulast=Wangdetection rateendometrial cytologymalignant cellovarian tumor |
| spellingShingle | Tiantian Wang Yadi Bin Lanbo Zhao Qiling Li Positive rate of malignant cells in endometrial cytology samples of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer patients: A systematic review and meta-analysis Journal of Cytology detection rate endometrial cytology malignant cell ovarian tumor |
| title | Positive rate of malignant cells in endometrial cytology samples of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer patients: A systematic review and meta-analysis |
| title_full | Positive rate of malignant cells in endometrial cytology samples of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer patients: A systematic review and meta-analysis |
| title_fullStr | Positive rate of malignant cells in endometrial cytology samples of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer patients: A systematic review and meta-analysis |
| title_full_unstemmed | Positive rate of malignant cells in endometrial cytology samples of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer patients: A systematic review and meta-analysis |
| title_short | Positive rate of malignant cells in endometrial cytology samples of ovarian cancer, fallopian tube cancer, and primary peritoneal cancer patients: A systematic review and meta-analysis |
| title_sort | positive rate of malignant cells in endometrial cytology samples of ovarian cancer fallopian tube cancer and primary peritoneal cancer patients a systematic review and meta analysis |
| topic | detection rate endometrial cytology malignant cell ovarian tumor |
| url | http://www.jcytol.org/article.asp?issn=0970-9371;year=2023;volume=40;issue=2;spage=51;epage=57;aulast=Wang |
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