Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China
Background and objects: The study aimed to evaluate the long-term neurological sequelae and the disease burden of JE in Gansu, China. Methods: JE patients were included as study population from 2005–2011 in Gansu, and a follow-up survey was conducted in 2007–2014. Pair-matched healthy individuals we...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Ubiquity Press
2021-10-01
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| Series: | Annals of Global Health |
| Online Access: | https://annalsofglobalhealth.org/articles/3343 |
| _version_ | 1818913998989426688 |
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| author | Xuxia Wang Li Su Shougang Sun Wenbiao Hu Qiuling Mu Xuefeng Liang Na Jin Tian Dai Hui Li Guihua Zhuang |
| author_facet | Xuxia Wang Li Su Shougang Sun Wenbiao Hu Qiuling Mu Xuefeng Liang Na Jin Tian Dai Hui Li Guihua Zhuang |
| author_sort | Xuxia Wang |
| collection | DOAJ |
| description | Background and objects: The study aimed to evaluate the long-term neurological sequelae and the disease burden of JE in Gansu, China. Methods: JE patients were included as study population from 2005–2011 in Gansu, and a follow-up survey was conducted in 2007–2014. Pair-matched healthy individuals were selected as controls. All subjects underwent a neurological examination and intelligence quotient (IQ) and memory quotient (MQ) assessments. Then, the disability-adjusted life years (DALYs), and direct and indirect medical expenses were systematic assessed. Results: Forty-four point seven percent of the JE patients had objective neurological deficits, compared with 2.4% of controls. Subnormal intelligence was found in 21.2% of JE subjects, compared with 1.2% control who exhibited a mildly reduced IQ. Abnormal MQ scores were noted in 56.3% JE subjects, compared with only 12.7% controls. Prevalence of each sequelae caused by JE were significantly higher in adults than in younger subjects. Furthermore, median DALY lost due to JE was 9.2 per subject. Median economic cost of JE was approximately $2776.6 per subject and significantly higher in adults than in younger subjects. Findings and Conclusions: JE patients suffered from severe neurological sequelae and high disease burden, resulting in a significant downstream burden for both the patients (especially adults) and the healthcare system. |
| first_indexed | 2024-12-19T23:39:24Z |
| format | Article |
| id | doaj.art-6f74f11c8e494918887c8befdac09a07 |
| institution | Directory Open Access Journal |
| issn | 2214-9996 |
| language | English |
| last_indexed | 2024-12-19T23:39:24Z |
| publishDate | 2021-10-01 |
| publisher | Ubiquity Press |
| record_format | Article |
| series | Annals of Global Health |
| spelling | doaj.art-6f74f11c8e494918887c8befdac09a072022-12-21T20:01:29ZengUbiquity PressAnnals of Global Health2214-99962021-10-0187110.5334/aogh.33432685Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, ChinaXuxia Wang0Li Su1Shougang Sun2Wenbiao Hu3Qiuling Mu4Xuefeng Liang5Na Jin6Tian Dai7Hui Li8Guihua Zhuang9Department of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061; Institute of Health Education, Gansu Provincial Center for Disease Control and Prevention, Lanzhou, 730000School of Public Health, Lanzhou University, Lanzhou 730000Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730000School of Public Health and Social Work, Queensland University of Technology, Kelvin Grove 4059, QLDGansu health vocational college, Lanzhou 730000Institute of Immunization Programme, Gansu Provincial Center for Disease Control and Prevention, Lanzhou, 730000Institute of Immunization Programme, Gansu Provincial Center for Disease Control and Prevention, Lanzhou, 730000School of Public Health, Lanzhou University, Lanzhou 730000Institute of prevention and control of infectious diseases, Gansu Provincial Center for Disease Control and Prevention, Lanzhou, 730000Department of Epidemiology and Biostatistics, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061Background and objects: The study aimed to evaluate the long-term neurological sequelae and the disease burden of JE in Gansu, China. Methods: JE patients were included as study population from 2005–2011 in Gansu, and a follow-up survey was conducted in 2007–2014. Pair-matched healthy individuals were selected as controls. All subjects underwent a neurological examination and intelligence quotient (IQ) and memory quotient (MQ) assessments. Then, the disability-adjusted life years (DALYs), and direct and indirect medical expenses were systematic assessed. Results: Forty-four point seven percent of the JE patients had objective neurological deficits, compared with 2.4% of controls. Subnormal intelligence was found in 21.2% of JE subjects, compared with 1.2% control who exhibited a mildly reduced IQ. Abnormal MQ scores were noted in 56.3% JE subjects, compared with only 12.7% controls. Prevalence of each sequelae caused by JE were significantly higher in adults than in younger subjects. Furthermore, median DALY lost due to JE was 9.2 per subject. Median economic cost of JE was approximately $2776.6 per subject and significantly higher in adults than in younger subjects. Findings and Conclusions: JE patients suffered from severe neurological sequelae and high disease burden, resulting in a significant downstream burden for both the patients (especially adults) and the healthcare system.https://annalsofglobalhealth.org/articles/3343 |
| spellingShingle | Xuxia Wang Li Su Shougang Sun Wenbiao Hu Qiuling Mu Xuefeng Liang Na Jin Tian Dai Hui Li Guihua Zhuang Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China Annals of Global Health |
| title | Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China |
| title_full | Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China |
| title_fullStr | Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China |
| title_full_unstemmed | Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China |
| title_short | Long-Term Neurological Sequelae and Disease Burden of Japanese Encephalitis in Gansu Province, China |
| title_sort | long term neurological sequelae and disease burden of japanese encephalitis in gansu province china |
| url | https://annalsofglobalhealth.org/articles/3343 |
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