The Effect of Novel Oleanolic Acid Oximes Conjugated with Indomethacin on the Nrf2-ARE And NF-κB Signaling Pathways in Normal Hepatocytes and Human Hepatocellular Cancer Cells

The Effect of Novel Oleanolic Acid Oximes Conjugated with Indomethacin on the Nrf2-ARE And NF-κB Signaling Pathways in Normal Hepatocytes and Human Hepatocellular Cancer Cells

Nrf2 and NF-κB play a key role in inflammation-driven cancers. Conjugation of anti-inflammatory drugs with oleanolic acid oxime (OAO) may enhance their therapeutic potential as a result of downregulation of these pathways. Novel OAO derivatives conjugated with indomethacin (IND) were synthesized, an...

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Bibliographic Details
Main Authors: Maria Narożna, Violetta Krajka-Kuźniak, Barbara Bednarczyk-Cwynar, Robert Kleszcz, Wanda Baer-Dubowska
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Pharmaceuticals
Subjects:
oleanolic acid oxime derivatives
indomethacin conjugates
NF-κB
Nrf2
HepG2 cells
THLE-2 cells
Online Access:https://www.mdpi.com/1424-8247/14/1/32

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