Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts
The purpose of the present study was to evaluate a possible interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with BMI and grade of obesity in the population of Yakuts Materials and Methods: A total of 191 people of Yakut nationality were tested (143 women and 48 men). Two groups of s...
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| Format: | Article |
| Language: | English |
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International Medical Research and Development Corporation
2019-09-01
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| Series: | International Journal of Biomedicine |
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| Online Access: | http://ijbm.org/articles/i35/ijbm_9(3)_oa4.pdf |
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| author | Nadezhda I. Pavlova Khariton A. Kurtanov, PhD Aleksandra T. Diakonova Natalia A. Solovyeva Ljubov' Ah. Sydykova Yulia A. Solovyeva |
| author_facet | Nadezhda I. Pavlova Khariton A. Kurtanov, PhD Aleksandra T. Diakonova Natalia A. Solovyeva Ljubov' Ah. Sydykova Yulia A. Solovyeva |
| author_sort | Nadezhda I. Pavlova |
| collection | DOAJ |
| description | The purpose of the present study was to evaluate a possible interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with BMI and grade of obesity in the population of Yakuts
Materials and Methods: A total of 191 people of Yakut nationality were tested (143 women and 48 men). Two groups of subjects were formed: the control group (CG) with BMI˂25 kg/m2 and the obesity group (OG) with BMI≥30 kg/m2. The study of the FTO rs9939609 SNP and the DAT1 rs27072 SNP was performed by PCR and restriction fragment length polymorphism.
Results: According to the results obtained from all persons surveyed, the frequency of the A risk allele of the FTO rs9939609 SNP was 27% with the AA genotype frequency of 9.4%. Analysis of the distribution of alleles and genotypes of the DAT1 rs27072 SNP showed the predominance of the wild-type G allele (90.8%) and the GG genotype in all groups (82.7%). Thus, in the Yakut population, a reliable relationship was found between the carriage of the A risk allele of the FTO SNP rs9939609 SNP with obesity and the degree of obesity. A significantly higher BMI was found in carriers of the wild-type G allele of the DAT1 rs27072 SNP, both in the heterozygous and homozygous forms than in the carriers of the homozygous AA genotype, which is probably related to the small number of people studied and requires careful research on larger samples of populations of Yakutia. |
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| id | doaj.art-6f763f9b19b1400381aabd9338c92a51 |
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| issn | 2158-0510 2158-0529 |
| language | English |
| last_indexed | 2024-12-16T12:02:22Z |
| publishDate | 2019-09-01 |
| publisher | International Medical Research and Development Corporation |
| record_format | Article |
| series | International Journal of Biomedicine |
| spelling | doaj.art-6f763f9b19b1400381aabd9338c92a512022-12-21T22:32:25ZengInternational Medical Research and Development CorporationInternational Journal of Biomedicine2158-05102158-05292019-09-019321021510.21103/Article9(3)_OA4Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of YakutsNadezhda I. Pavlova0Khariton A. Kurtanov, PhD1Aleksandra T. Diakonova2Natalia A. Solovyeva3Ljubov' Ah. Sydykova4Yulia A. Solovyeva5Yakut Science Center of Complex Medical Problems, Yakutsk, the Republic of Sakha (Yakutia), RussiaYakut Science Center of Complex Medical Problems, Yakutsk, the Republic of Sakha (Yakutia), RussiaYakut Science Center of Complex Medical Problems, Yakutsk, the Republic of Sakha (Yakutia), RussiaYakut Science Center of Complex Medical Problems, Yakutsk, the Republic of Sakha (Yakutia), RussiaM. K. Ammosov North-Eastern Federal University; Yakut Republican Clinical Hospital; Yakutsk, the Republic of Sakha (Yakutia), RussiaYakut Science Center of Complex Medical Problems, Yakutsk, the Republic of Sakha (Yakutia), RussiaThe purpose of the present study was to evaluate a possible interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with BMI and grade of obesity in the population of Yakuts Materials and Methods: A total of 191 people of Yakut nationality were tested (143 women and 48 men). Two groups of subjects were formed: the control group (CG) with BMI˂25 kg/m2 and the obesity group (OG) with BMI≥30 kg/m2. The study of the FTO rs9939609 SNP and the DAT1 rs27072 SNP was performed by PCR and restriction fragment length polymorphism. Results: According to the results obtained from all persons surveyed, the frequency of the A risk allele of the FTO rs9939609 SNP was 27% with the AA genotype frequency of 9.4%. Analysis of the distribution of alleles and genotypes of the DAT1 rs27072 SNP showed the predominance of the wild-type G allele (90.8%) and the GG genotype in all groups (82.7%). Thus, in the Yakut population, a reliable relationship was found between the carriage of the A risk allele of the FTO SNP rs9939609 SNP with obesity and the degree of obesity. A significantly higher BMI was found in carriers of the wild-type G allele of the DAT1 rs27072 SNP, both in the heterozygous and homozygous forms than in the carriers of the homozygous AA genotype, which is probably related to the small number of people studied and requires careful research on larger samples of populations of Yakutia.http://ijbm.org/articles/i35/ijbm_9(3)_oa4.pdfBMIobesityFTODAT1eating disorders |
| spellingShingle | Nadezhda I. Pavlova Khariton A. Kurtanov, PhD Aleksandra T. Diakonova Natalia A. Solovyeva Ljubov' Ah. Sydykova Yulia A. Solovyeva Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts International Journal of Biomedicine BMI obesity FTO DAT1 eating disorders |
| title | Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts |
| title_full | Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts |
| title_fullStr | Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts |
| title_full_unstemmed | Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts |
| title_short | Interrelation of the FTO rs9939609 SNP and the DAT1 rs27072 SNP with Body Mass Index and Degree of Obesity in the Population of Yakuts |
| title_sort | interrelation of the fto rs9939609 snp and the dat1 rs27072 snp with body mass index and degree of obesity in the population of yakuts |
| topic | BMI obesity FTO DAT1 eating disorders |
| url | http://ijbm.org/articles/i35/ijbm_9(3)_oa4.pdf |
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