Oxidative stress and hepatotoxicity in rats induced by poisonous pufferfish (Lagocephalus lagocephalus) meat
This study was undertaken to evaluate the effect of pufferfish (Lagocephalus lagocephalus) meat poisoning on hepatic functions of Wistar rats. For this purpose, groups of rats (Lcr, Lcu+b and Lcu-b) received diet supplemented with 10% of raw or cooked meat, respectively, with or without cooking wate...
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| Format: | Article |
| Language: | English |
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SciELO
2009-01-01
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| Series: | Journal of Venomous Animals and Toxins including Tropical Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300006 |
| _version_ | 1828304594238701568 |
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| author | M Saoudi A Abdelmouleh F Ellouze K Jamoussi A El Feki |
| author_facet | M Saoudi A Abdelmouleh F Ellouze K Jamoussi A El Feki |
| author_sort | M Saoudi |
| collection | DOAJ |
| description | This study was undertaken to evaluate the effect of pufferfish (Lagocephalus lagocephalus) meat poisoning on hepatic functions of Wistar rats. For this purpose, groups of rats (Lcr, Lcu+b and Lcu-b) received diet supplemented with 10% of raw or cooked meat, respectively, with or without cooking water of L. lagocephalus while groups Mcr and Mcu+b received diet supplemented with 10% of raw or cooked meat of Liza aurata, which were used as a negative control. In Lcu+b group, ALT, AST and ALP rates (hepatic enzyme markers) decreased after two months of treatment, indicating liver damage. We also observed an increase of 54 and 65% of thiobarbituric acid reactive substances (TBARS) in their livers respectively 48 hours and two months after treatment compared to controls. The catalase (CAT) activity in group Lcu+b decreased (p < 0.05) after two periods of treatment, whereas metallothionein (MT) level significantly increased and decreased, respectively after 48 hours and two months. In fact, in the histological analysis of the livers from Lcu+b treated group, we observed an increase in vacuolisation, necrosis, hepatocytes ballooning and sinusoids dilation. These results indicate that L. lagocephalus meat cooked with water produces hepatotoxicity and oxidative damage. |
| first_indexed | 2024-04-13T14:13:11Z |
| format | Article |
| id | doaj.art-6f76ba69622545a7a94074163aedc5db |
| institution | Directory Open Access Journal |
| issn | 1678-9199 |
| language | English |
| last_indexed | 2024-04-13T14:13:11Z |
| publishDate | 2009-01-01 |
| publisher | SciELO |
| record_format | Article |
| series | Journal of Venomous Animals and Toxins including Tropical Diseases |
| spelling | doaj.art-6f76ba69622545a7a94074163aedc5db2022-12-22T02:43:43ZengSciELOJournal of Venomous Animals and Toxins including Tropical Diseases1678-91992009-01-0115342444310.1590/S1678-91992009000300006Oxidative stress and hepatotoxicity in rats induced by poisonous pufferfish (Lagocephalus lagocephalus) meatM SaoudiA AbdelmoulehF EllouzeK JamoussiA El FekiThis study was undertaken to evaluate the effect of pufferfish (Lagocephalus lagocephalus) meat poisoning on hepatic functions of Wistar rats. For this purpose, groups of rats (Lcr, Lcu+b and Lcu-b) received diet supplemented with 10% of raw or cooked meat, respectively, with or without cooking water of L. lagocephalus while groups Mcr and Mcu+b received diet supplemented with 10% of raw or cooked meat of Liza aurata, which were used as a negative control. In Lcu+b group, ALT, AST and ALP rates (hepatic enzyme markers) decreased after two months of treatment, indicating liver damage. We also observed an increase of 54 and 65% of thiobarbituric acid reactive substances (TBARS) in their livers respectively 48 hours and two months after treatment compared to controls. The catalase (CAT) activity in group Lcu+b decreased (p < 0.05) after two periods of treatment, whereas metallothionein (MT) level significantly increased and decreased, respectively after 48 hours and two months. In fact, in the histological analysis of the livers from Lcu+b treated group, we observed an increase in vacuolisation, necrosis, hepatocytes ballooning and sinusoids dilation. These results indicate that L. lagocephalus meat cooked with water produces hepatotoxicity and oxidative damage.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300006hepatotoxicityLagocephalus lagocephalusoxidative stresstetrodotoxin |
| spellingShingle | M Saoudi A Abdelmouleh F Ellouze K Jamoussi A El Feki Oxidative stress and hepatotoxicity in rats induced by poisonous pufferfish (Lagocephalus lagocephalus) meat Journal of Venomous Animals and Toxins including Tropical Diseases hepatotoxicity Lagocephalus lagocephalus oxidative stress tetrodotoxin |
| title | Oxidative stress and hepatotoxicity in rats induced by poisonous pufferfish (Lagocephalus lagocephalus) meat |
| title_full | Oxidative stress and hepatotoxicity in rats induced by poisonous pufferfish (Lagocephalus lagocephalus) meat |
| title_fullStr | Oxidative stress and hepatotoxicity in rats induced by poisonous pufferfish (Lagocephalus lagocephalus) meat |
| title_full_unstemmed | Oxidative stress and hepatotoxicity in rats induced by poisonous pufferfish (Lagocephalus lagocephalus) meat |
| title_short | Oxidative stress and hepatotoxicity in rats induced by poisonous pufferfish (Lagocephalus lagocephalus) meat |
| title_sort | oxidative stress and hepatotoxicity in rats induced by poisonous pufferfish lagocephalus lagocephalus meat |
| topic | hepatotoxicity Lagocephalus lagocephalus oxidative stress tetrodotoxin |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300006 |
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