Herpes Simplex Virus 1 Deregulation of Host MicroRNAs
Viruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and mechanisms, apparently far beyond the classical understanding of gene repression in humans. Likewise, herpes simplex virus 1 (HSV-1) expresses numerous miRNAs and deregulates the expression of host miRNAs. Several HSV-...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-11-01
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| Series: | Non-Coding RNA |
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| Online Access: | https://www.mdpi.com/2311-553X/4/4/36 |
| _version_ | 1818021967597404160 |
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| author | Maja Cokarić Brdovčak Andreja Zubković Igor Jurak |
| author_facet | Maja Cokarić Brdovčak Andreja Zubković Igor Jurak |
| author_sort | Maja Cokarić Brdovčak |
| collection | DOAJ |
| description | Viruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and mechanisms, apparently far beyond the classical understanding of gene repression in humans. Likewise, herpes simplex virus 1 (HSV-1) expresses numerous miRNAs and deregulates the expression of host miRNAs. Several HSV-1 miRNAs are abundantly expressed in latency, some of which are encoded antisense to transcripts of important productive infection genes, indicating their roles in repressing the productive cycle and/or in maintenance/reactivation from latency. In addition, HSV-1 also exploits host miRNAs to advance its replication or repress its genes to facilitate latency. Here, we discuss what is known about the functional interplay between HSV-1 and the host miRNA machinery, potential targets, and the molecular mechanisms leading to an efficient virus replication and spread. |
| first_indexed | 2024-04-14T08:25:25Z |
| format | Article |
| id | doaj.art-6f79cee6ba944ad1918f51d8c1bfb978 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-04-14T08:25:25Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-6f79cee6ba944ad1918f51d8c1bfb9782022-12-22T02:04:05ZengMDPI AGNon-Coding RNA2311-553X2018-11-01443610.3390/ncrna4040036ncrna4040036Herpes Simplex Virus 1 Deregulation of Host MicroRNAsMaja Cokarić Brdovčak0Andreja Zubković1Igor Jurak2Laboratory for Molecular Virology, Department of Biotechnology, University of Rijeka, R. Matejčić 2, HR-51000 Rijeka, CroatiaLaboratory for Molecular Virology, Department of Biotechnology, University of Rijeka, R. Matejčić 2, HR-51000 Rijeka, CroatiaLaboratory for Molecular Virology, Department of Biotechnology, University of Rijeka, R. Matejčić 2, HR-51000 Rijeka, CroatiaViruses utilize microRNAs (miRNAs) in a vast variety of possible interactions and mechanisms, apparently far beyond the classical understanding of gene repression in humans. Likewise, herpes simplex virus 1 (HSV-1) expresses numerous miRNAs and deregulates the expression of host miRNAs. Several HSV-1 miRNAs are abundantly expressed in latency, some of which are encoded antisense to transcripts of important productive infection genes, indicating their roles in repressing the productive cycle and/or in maintenance/reactivation from latency. In addition, HSV-1 also exploits host miRNAs to advance its replication or repress its genes to facilitate latency. Here, we discuss what is known about the functional interplay between HSV-1 and the host miRNA machinery, potential targets, and the molecular mechanisms leading to an efficient virus replication and spread.https://www.mdpi.com/2311-553X/4/4/36miRNAshost–pathogen interactionHSV-1latencyproductive replicationantiviral innate immune responseapoptosis |
| spellingShingle | Maja Cokarić Brdovčak Andreja Zubković Igor Jurak Herpes Simplex Virus 1 Deregulation of Host MicroRNAs Non-Coding RNA miRNAs host–pathogen interaction HSV-1 latency productive replication antiviral innate immune response apoptosis |
| title | Herpes Simplex Virus 1 Deregulation of Host MicroRNAs |
| title_full | Herpes Simplex Virus 1 Deregulation of Host MicroRNAs |
| title_fullStr | Herpes Simplex Virus 1 Deregulation of Host MicroRNAs |
| title_full_unstemmed | Herpes Simplex Virus 1 Deregulation of Host MicroRNAs |
| title_short | Herpes Simplex Virus 1 Deregulation of Host MicroRNAs |
| title_sort | herpes simplex virus 1 deregulation of host micrornas |
| topic | miRNAs host–pathogen interaction HSV-1 latency productive replication antiviral innate immune response apoptosis |
| url | https://www.mdpi.com/2311-553X/4/4/36 |
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