Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates
Abstract Background Two Labrador retriever littermates were identified based on incidentally noted marked microcytosis and inappropriate metarubricytosis. Muscle atrophy was noted and associated with distinctive pathological findings in biopsy samples from 1 dog studied. The disorder represents a ra...
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| Format: | Article |
| Language: | English |
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Wiley
2021-09-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16214 |
| _version_ | 1819292711036911616 |
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| author | Alison Thomas‐Hollands G. Diane Shelton Ling T. Guo Kerry Loughran Gregory Kaiman Tabitha A.Hutton Koranda A. Walsh |
| author_facet | Alison Thomas‐Hollands G. Diane Shelton Ling T. Guo Kerry Loughran Gregory Kaiman Tabitha A.Hutton Koranda A. Walsh |
| author_sort | Alison Thomas‐Hollands |
| collection | DOAJ |
| description | Abstract Background Two Labrador retriever littermates were identified based on incidentally noted marked microcytosis and inappropriate metarubricytosis. Muscle atrophy was noted and associated with distinctive pathological findings in biopsy samples from 1 dog studied. The disorder represents a rare clinical entity of suspected congenital dyserythropoiesis and polymyopathy. Clinicopathologic changes were similar to a previously reported syndrome of congenital dyserythropoiesis, congenital polymyopathy, and cardiac disease in 3 related English Springer Spaniel (ESS) dogs, but the dogs reported here did not have apparent cardiac disease. Interventions Bone marrow aspiration, electromyography, muscle biopsies, and an echocardiogram were performed on dog 1. Results supported dyserythropoiesis and congenital polymyopathy similar to reports in ESS dogs, but did not identify obvious cardiac disease. Conclusion The clinicopathologic changes of dyserythropoiesis and polymyopathy provide an easily recognizable phenotype for what appears to be a low morbidity syndrome. Early recognition may decrease unnecessary testing or euthanasia. |
| first_indexed | 2024-12-24T03:58:52Z |
| format | Article |
| id | doaj.art-6f7a336f448747e4a87851cc1f63412f |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-12-24T03:58:52Z |
| publishDate | 2021-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-6f7a336f448747e4a87851cc1f63412f2022-12-21T17:16:21ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762021-09-013552409241410.1111/jvim.16214Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermatesAlison Thomas‐Hollands0G. Diane Shelton1Ling T. Guo2Kerry Loughran3Gregory Kaiman4Tabitha A.Hutton5Koranda A. Walsh6Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania Philadelphia Pennsylvania USADepartment of Pathology University of California San Diego La Jolla California USADepartment of Pathology University of California San Diego La Jolla California USADepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania Philadelphia Pennsylvania USADepartment of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine University of Pennsylvania Philadelphia Pennsylvania USAMetropolitan Veterinary Associates Norristown Pennsylvania USADepartment of Pathobiology, School of Veterinary Medicine University of Pennsylvania Philadelphia Pennsylvania USAAbstract Background Two Labrador retriever littermates were identified based on incidentally noted marked microcytosis and inappropriate metarubricytosis. Muscle atrophy was noted and associated with distinctive pathological findings in biopsy samples from 1 dog studied. The disorder represents a rare clinical entity of suspected congenital dyserythropoiesis and polymyopathy. Clinicopathologic changes were similar to a previously reported syndrome of congenital dyserythropoiesis, congenital polymyopathy, and cardiac disease in 3 related English Springer Spaniel (ESS) dogs, but the dogs reported here did not have apparent cardiac disease. Interventions Bone marrow aspiration, electromyography, muscle biopsies, and an echocardiogram were performed on dog 1. Results supported dyserythropoiesis and congenital polymyopathy similar to reports in ESS dogs, but did not identify obvious cardiac disease. Conclusion The clinicopathologic changes of dyserythropoiesis and polymyopathy provide an easily recognizable phenotype for what appears to be a low morbidity syndrome. Early recognition may decrease unnecessary testing or euthanasia.https://doi.org/10.1111/jvim.16214anemiadyserythropoiesismetarubricytosismicrocytosismuscle atrophypolymyopathy |
| spellingShingle | Alison Thomas‐Hollands G. Diane Shelton Ling T. Guo Kerry Loughran Gregory Kaiman Tabitha A.Hutton Koranda A. Walsh Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates Journal of Veterinary Internal Medicine anemia dyserythropoiesis metarubricytosis microcytosis muscle atrophy polymyopathy |
| title | Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates |
| title_full | Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates |
| title_fullStr | Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates |
| title_full_unstemmed | Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates |
| title_short | Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates |
| title_sort | congenital dyserythropoiesis and polymyopathy without cardiac disease in male labrador retriever littermates |
| topic | anemia dyserythropoiesis metarubricytosis microcytosis muscle atrophy polymyopathy |
| url | https://doi.org/10.1111/jvim.16214 |
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