Mutation Patterns of Human SARS-CoV-2 and Bat RaTG13 Coronavirus Genomes Are Strongly Biased Towards C>U Transitions, Indicating Rapid Evolution in Their Hosts

Mutation Patterns of Human SARS-CoV-2 and Bat RaTG13 Coronavirus Genomes Are Strongly Biased Towards C>U Transitions, Indicating Rapid Evolution in Their Hosts

The pandemic caused by the spread of SARS-CoV-2 has led to considerable interest in its evolutionary origin and genome structure. Here, we analyzed mutation patterns in 34 human SARS-CoV-2 isolates and a closely related RaTG13 isolated from <i>Rhinolophus affinis</i> (a horseshoe bat). W...

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Bibliographic Details
Main Authors: Roman Matyášek, Aleš Kovařík
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Genes
Subjects:
evolution
cytosine deamination
CpG depletion
coronavirus
SARS-CoV-2
mutation bias
Online Access:https://www.mdpi.com/2073-4425/11/7/761

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