Proximal and Distal Regions of Pathogenic Th17 Related Chromatin Loci Are Sequentially Accessible During Pathogenicity of Th17

Proximal and Distal Regions of Pathogenic Th17 Related Chromatin Loci Are Sequentially Accessible During Pathogenicity of Th17

Pathogenic Th17, featured by their production of pro-inflammatory cytokines, are considered as a key player in most autoimmune diseases. The transcriptome of them is obviously distinct from that of conventional regulatory Th17. However, chromatin accessibility of the two Th17 groups have not been co...

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Bibliographic Details
Main Authors: Luni Hu, Xingyu Zhao, Peng Li, Yanyu Zeng, Yime Zhang, Yang Shen, Yukai Wang, Xiaolin Sun, Binbin Lai, Chao Zhong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
autoimmune disease
regulatory Th17
pathogenic Th17
pro-inflammatory Th1
chromatin accessibility
transcriptional regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.864314/full

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