The novel PPAR α/γ dual agonist MHY 966 modulates UVB-induced skin inflammation by inhibiting NF-κB activity.

The novel PPAR α/γ dual agonist MHY 966 modulates UVB-induced skin inflammation by inhibiting NF-κB activity.

Ultraviolet B (UVB; 290~320nm) irradiation-induced lipid peroxidation induces inflammatory responses that lead to skin wrinkle formation and epidermal thickening. Peroxisome proliferator-activated receptor (PPAR) α/γ dual agonists have the potential to be used as anti-wrinkle agents because they inh...

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Bibliographic Details
Main Authors: Min Hi Park, Ji Young Park, Hye Jin Lee, Dae Hyun Kim, Ki Wung Chung, Daeui Park, Hyoung Oh Jeong, Hye Rim Kim, Chan Hum Park, So Ra Kim, Pusoon Chun, Youngjoo Byun, Hyung Ryong Moon, Hae Young Chung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3793945?pdf=render

Internet

http://europepmc.org/articles/PMC3793945?pdf=render

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