Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus [version 1; peer review: 1 approved, 2 approved with reservations]

Single-cell multi-omics analysis reveals IFN-driven alterations in T lymphocytes and natural killer cells in systemic lupus erythematosus [version 1; peer review: 1 approved, 2 approved with reservations]

Background: The characterisation of the peripheral immune system in the autoimmune disease systemic lupus erythematosus (SLE) at the single-cell level has been limited by the reduced sensitivity of current whole-transcriptomic technologies. Here we employ a targeted single-cell multi-omics approach,...

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Bibliographic Details
Main Authors: Dominik Trzupek, Fiona Hamey, Mercede Lee, John A. Todd, Linda S. Wicker, Ricardo C. Ferreira
Format: Article
Language:English
Published: Wellcome 2021-06-01
Series:Wellcome Open Research
Subjects:
Single-cell RNA-sequencing (scRNA-seq)
multi-omics
BD Rhapsody
AbSeq
cytotoxic CD4+ T cells (CTLs)
systemic lupus erythematosus (SLE)
eng
Online Access:https://wellcomeopenresearch.org/articles/6-149/v1

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