Interpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer Immunotherapy

Interpreting T-Cell Cross-reactivity through Structure: Implications for TCR-Based Cancer Immunotherapy

Immunotherapy has become one of the most promising avenues for cancer treatment, making use of the patient’s own immune system to eliminate cancer cells. Clinical trials with T-cell-based immunotherapies have shown dramatic tumor regressions, being effective in multiple cancer types and for many dif...

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Bibliographic Details
Main Authors: Dinler A. Antunes, Maurício M. Rigo, Martiela V. Freitas, Marcus F. A. Mendes, Marialva Sinigaglia, Gregory Lizée, Lydia E. Kavraki, Liisa K. Selin, Markus Cornberg, Gustavo F. Vieira
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
T-cell cross-reactivity
peptide–MHC complex
cross-reactivity hot-spots
TCR-interacting surface
hierarchical clustering
TCR/pMHC
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01210/full

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