CXCR3 antagonism of SDF-1(5-67) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertension.

CXCR3 antagonism of SDF-1(5-67) restores trabecular function and prevents retinal neurodegeneration in a rat model of ocular hypertension.

Glaucoma, the most common cause of irreversible blindness, is a neuropathy commonly initiated by pathological ocular hypertension due to unknown mechanisms of trabecular meshwork degeneration. Current antiglaucoma therapy does not target the causal trabecular pathology, which may explain why treatme...

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Bibliographic Details
Main Authors: Alexandre Denoyer, David Godefroy, Isabelle Célérier, Julie Frugier, Julie Degardin, Jeffrey K Harrison, Francoise Brignole-Baudouin, Serge Picaud, Francoise Baleux, José A Sahel, William Rostène, Christophe Baudouin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3366966?pdf=render

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