Expression of Genomic Instability-Related Molecules: Cyclin F, RRM2 and SPDL1 and Their Prognostic Significance in Pancreatic Adenocarcinoma

Expression of Genomic Instability-Related Molecules: Cyclin F, RRM2 and SPDL1 and Their Prognostic Significance in Pancreatic Adenocarcinoma

In the present study, we aimed to assess the selected components of cell cycle machinery, checkpoint, DNA repair, and synthesis, namely RRM2, cyclin F, and SPDL1 in pancreatic adenocarcinomas (PAC) by in-house immunohistochemistry (IHC) and bioinformatic analysis of public datasets, in terms of expr...

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Bibliographic Details
Main Authors: Anna Klimaszewska-Wiśniewska, Karolina Buchholz, Izabela Neska-Długosz, Justyna Durślewicz, Dariusz Grzanka, Jan Zabrzyński, Paulina Sopońska, Alina Grzanka, Maciej Gagat
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
pancreatic ductal adenocarcinoma
cyclin F
RRM2
SPDL1
genomic instability
prognostic factor
Online Access:https://www.mdpi.com/2072-6694/13/4/859

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