CDK1-Mediated Phosphorylation of BAG3 Promotes Mitotic Cell Shape Remodeling and the Molecular Assembly of Mitotic p62 Bodies

CDK1-Mediated Phosphorylation of BAG3 Promotes Mitotic Cell Shape Remodeling and the Molecular Assembly of Mitotic p62 Bodies

The cochaperone BCL2-associated athanogene 3 (BAG3), in complex with the heat shock protein HSPB8, facilitates mitotic rounding, spindle orientation, and proper abscission of daughter cells. BAG3 and HSPB8 mitotic functions implicate the sequestosome p62/SQSTM1, suggesting a role for protein quality...

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Bibliographic Details
Main Authors: Carole Luthold, Herman Lambert, Solenn M. Guilbert, Marc-Antoine Rodrigue, Margit Fuchs, Alice-Anaïs Varlet, Amélie Fradet-Turcotte, Josée N. Lavoie
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cells
Subjects:
BAG3 1
HSPB8 2
p62/SQSTM1 bodies 3
CDK1 4
spindle positioning 5
mitotic cell rounding 6
Online Access:https://www.mdpi.com/2073-4409/10/10/2638

Internet

https://www.mdpi.com/2073-4409/10/10/2638

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