Roundup<sup>®</sup>, but Not Roundup-Ready<sup>®</sup> Corn, Increases Mortality of <i>Drosophila melanogaster</i>
Genetically modified foods have become pervasive in diets of people living in the US. By far the most common genetically modified foods either tolerate herbicide application (HT) or produce endogenous insecticide (Bt). To determine whether these toxicological effects result from genetic modification...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-07-01
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| Series: | Toxics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2305-6304/7/3/38 |
| _version_ | 1831647284879687680 |
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| author | Becky Talyn Rachael Lemon Maryam Badoella Darwin Melchiorre Maryori Villalobos Raquel Elias Kelly Muller Maggie Santos Erik Melchiorre |
| author_facet | Becky Talyn Rachael Lemon Maryam Badoella Darwin Melchiorre Maryori Villalobos Raquel Elias Kelly Muller Maggie Santos Erik Melchiorre |
| author_sort | Becky Talyn |
| collection | DOAJ |
| description | Genetically modified foods have become pervasive in diets of people living in the US. By far the most common genetically modified foods either tolerate herbicide application (HT) or produce endogenous insecticide (Bt). To determine whether these toxicological effects result from genetic modification <i>per se</i>, or from the increase in herbicide or insecticide residues present on the food, we exposed fruit flies, <i>Drosophila melanogaster</i>, to food containing HT corn that had been sprayed with the glyphosate-based herbicide Roundup<sup>®</sup>, HT corn that had not been sprayed with Roundup<sup>®</sup>, or Roundup<sup>®</sup> in a variety of known glyphosate concentrations and formulations. While neither lifespan nor reproductive behaviors were affected by HT corn, addition of Roundup<sup>®</sup> increased mortality with an LC<sub>50</sub> of 7.1 g/L for males and 11.4 g/L for females after 2 days of exposure. Given the many genetic tools available, <i>Drosophila</i> are an excellent model system for future studies about genetic and biochemical mechanisms of glyphosate toxicity. |
| first_indexed | 2024-12-19T14:10:48Z |
| format | Article |
| id | doaj.art-6f8b094d637f4ba2ba6c30160a22d0fe |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-12-19T14:10:48Z |
| publishDate | 2019-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-6f8b094d637f4ba2ba6c30160a22d0fe2022-12-21T20:18:08ZengMDPI AGToxics2305-63042019-07-01733810.3390/toxics7030038toxics7030038Roundup<sup>®</sup>, but Not Roundup-Ready<sup>®</sup> Corn, Increases Mortality of <i>Drosophila melanogaster</i>Becky Talyn0Rachael Lemon1Maryam Badoella2Darwin Melchiorre3Maryori Villalobos4Raquel Elias5Kelly Muller6Maggie Santos7Erik Melchiorre8College of Natural Science, California State University, 5500 University Parkway, San Bernardino, CA 92407, USABiology Department, California State University, 5500 University Parkway, San Bernardino, CA 92407, USABiology Department, California State University, 5500 University Parkway, San Bernardino, CA 92407, USACanyon Kids Academy, 7883 Stewart Road, Colton, CA 92324, USABiology Department, California State University, 5500 University Parkway, San Bernardino, CA 92407, USABiology Department, California State University, 5500 University Parkway, San Bernardino, CA 92407, USAChemistry and Biochemistry Department, California State University, 5500 University Parkway, San Bernardino, CA 92407, USABiology Department, California State University, 5500 University Parkway, San Bernardino, CA 92407, USAGeology Department, California State University, 5500 University Parkway, San Bernardino, CA 92407, USAGenetically modified foods have become pervasive in diets of people living in the US. By far the most common genetically modified foods either tolerate herbicide application (HT) or produce endogenous insecticide (Bt). To determine whether these toxicological effects result from genetic modification <i>per se</i>, or from the increase in herbicide or insecticide residues present on the food, we exposed fruit flies, <i>Drosophila melanogaster</i>, to food containing HT corn that had been sprayed with the glyphosate-based herbicide Roundup<sup>®</sup>, HT corn that had not been sprayed with Roundup<sup>®</sup>, or Roundup<sup>®</sup> in a variety of known glyphosate concentrations and formulations. While neither lifespan nor reproductive behaviors were affected by HT corn, addition of Roundup<sup>®</sup> increased mortality with an LC<sub>50</sub> of 7.1 g/L for males and 11.4 g/L for females after 2 days of exposure. Given the many genetic tools available, <i>Drosophila</i> are an excellent model system for future studies about genetic and biochemical mechanisms of glyphosate toxicity.https://www.mdpi.com/2305-6304/7/3/38Roundup<sup>®</sup>glyphosateLC<sub>50</sub><i>Drosophila melanogaster</i>herbicide tolerantgenetically modified food |
| spellingShingle | Becky Talyn Rachael Lemon Maryam Badoella Darwin Melchiorre Maryori Villalobos Raquel Elias Kelly Muller Maggie Santos Erik Melchiorre Roundup<sup>®</sup>, but Not Roundup-Ready<sup>®</sup> Corn, Increases Mortality of <i>Drosophila melanogaster</i> Toxics Roundup<sup>®</sup> glyphosate LC<sub>50</sub> <i>Drosophila melanogaster</i> herbicide tolerant genetically modified food |
| title | Roundup<sup>®</sup>, but Not Roundup-Ready<sup>®</sup> Corn, Increases Mortality of <i>Drosophila melanogaster</i> |
| title_full | Roundup<sup>®</sup>, but Not Roundup-Ready<sup>®</sup> Corn, Increases Mortality of <i>Drosophila melanogaster</i> |
| title_fullStr | Roundup<sup>®</sup>, but Not Roundup-Ready<sup>®</sup> Corn, Increases Mortality of <i>Drosophila melanogaster</i> |
| title_full_unstemmed | Roundup<sup>®</sup>, but Not Roundup-Ready<sup>®</sup> Corn, Increases Mortality of <i>Drosophila melanogaster</i> |
| title_short | Roundup<sup>®</sup>, but Not Roundup-Ready<sup>®</sup> Corn, Increases Mortality of <i>Drosophila melanogaster</i> |
| title_sort | roundup sup r sup but not roundup ready sup r sup corn increases mortality of i drosophila melanogaster i |
| topic | Roundup<sup>®</sup> glyphosate LC<sub>50</sub> <i>Drosophila melanogaster</i> herbicide tolerant genetically modified food |
| url | https://www.mdpi.com/2305-6304/7/3/38 |
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