Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease
Selenium (Se), an essential antioxidant trace element, is reported to play a role in Parkinson’s disease (PD). However, there is a lack of systematic studies on different Se forms against PD. Our study is designed to compare the neuroprotective effects of inorganic and organic Se in two classical PD...
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MDPI AG
2022-12-01
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| author | Chongchong Sun Zhongrui Du Xin Liu Ye Yang Sainan Zhou Chong Li Xu Cao Qing Zhao Kahing Wong Wenfang Chen Xiaoli Dong |
| author_facet | Chongchong Sun Zhongrui Du Xin Liu Ye Yang Sainan Zhou Chong Li Xu Cao Qing Zhao Kahing Wong Wenfang Chen Xiaoli Dong |
| author_sort | Chongchong Sun |
| collection | DOAJ |
| description | Selenium (Se), an essential antioxidant trace element, is reported to play a role in Parkinson’s disease (PD). However, there is a lack of systematic studies on different Se forms against PD. Our study is designed to compare the neuroprotective effects of inorganic and organic Se in two classical PD mice models and investigate the underlying mechanisms for their potentially differential actions against PD. In this study, different dosages of inorganic sodium selenite (Se-Na) or organic seleno-L-methionine (Se-Met) were fed to either acute or chronic PD mice models, and their neuroprotective effects and mechanisms were explored and compared. Se-Na provided better neuroprotective effects in PD mice than Se-Met administered at the same but at a relatively low Se dosage. Se-Na treatment could influence GPX activities but not their mRNA expressions in the midbrains of PD mice. The enhanced GPX activities caused by Se-Na, but not Se-Met, in PD mice could be the major reason for the positive actions of inorganic Se to prevent dopaminergic neuronal loss in this study. <i>In vivo</i> bio-distribution experiments found MPTP injection greatly changed Se bio-distribution in mice, which led to reversed alterations in the bioavailability of Se-Met and Se-Na. Se-Na had higher bioavailability than Se-Met in PD mice, which could explain its better neuroprotective effects compared to Se-Met. Our results proved that Se forms and dosages determined their biological actions in mouse models of PD. Our study will provide valuable scientific evidence to researchers and/or medical professionals in using Se for PD prevention or therapy. |
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| spelling | doaj.art-6f8d8d2e6e0e455d84e135b4899ac5d32023-12-02T00:45:25ZengMDPI AGNutrients2072-66432022-12-011511110.3390/nu15010011Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s DiseaseChongchong Sun0Zhongrui Du1Xin Liu2Ye Yang3Sainan Zhou4Chong Li5Xu Cao6Qing Zhao7Kahing Wong8Wenfang Chen9Xiaoli Dong10Department of Physiology, School of Basic Medicine, Qingdao University, Qingdao 266071, ChinaThe Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, ChinaThe Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, ChinaResearch Institute for Future Food, The Hong Kong Polytechnic University, Hong Kong 852, ChinaThe Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, ChinaResearch Institute for Future Food, The Hong Kong Polytechnic University, Hong Kong 852, ChinaDepartment of Neurology, Shenzhen University General Hospital, Shenzhen University Clinical Medical Academy, Shenzhen 518055, ChinaDepartment of Neurology, Linzi Maternal & Child Health Hospital of Zibo, Zibo 255400, ChinaThe Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, ChinaDepartment of Physiology, School of Basic Medicine, Qingdao University, Qingdao 266071, ChinaThe Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen 518057, ChinaSelenium (Se), an essential antioxidant trace element, is reported to play a role in Parkinson’s disease (PD). However, there is a lack of systematic studies on different Se forms against PD. Our study is designed to compare the neuroprotective effects of inorganic and organic Se in two classical PD mice models and investigate the underlying mechanisms for their potentially differential actions against PD. In this study, different dosages of inorganic sodium selenite (Se-Na) or organic seleno-L-methionine (Se-Met) were fed to either acute or chronic PD mice models, and their neuroprotective effects and mechanisms were explored and compared. Se-Na provided better neuroprotective effects in PD mice than Se-Met administered at the same but at a relatively low Se dosage. Se-Na treatment could influence GPX activities but not their mRNA expressions in the midbrains of PD mice. The enhanced GPX activities caused by Se-Na, but not Se-Met, in PD mice could be the major reason for the positive actions of inorganic Se to prevent dopaminergic neuronal loss in this study. <i>In vivo</i> bio-distribution experiments found MPTP injection greatly changed Se bio-distribution in mice, which led to reversed alterations in the bioavailability of Se-Met and Se-Na. Se-Na had higher bioavailability than Se-Met in PD mice, which could explain its better neuroprotective effects compared to Se-Met. Our results proved that Se forms and dosages determined their biological actions in mouse models of PD. Our study will provide valuable scientific evidence to researchers and/or medical professionals in using Se for PD prevention or therapy.https://www.mdpi.com/2072-6643/15/1/11Parkinson’s diseaseseleniumsodium seleniteseleno-L-methionineselenoproteins |
| spellingShingle | Chongchong Sun Zhongrui Du Xin Liu Ye Yang Sainan Zhou Chong Li Xu Cao Qing Zhao Kahing Wong Wenfang Chen Xiaoli Dong Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease Nutrients Parkinson’s disease selenium sodium selenite seleno-L-methionine selenoproteins |
| title | Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease |
| title_full | Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease |
| title_fullStr | Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease |
| title_full_unstemmed | Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease |
| title_short | Selenium Forms and Dosages Determined Their Biological Actions in Mouse Models of Parkinson’s Disease |
| title_sort | selenium forms and dosages determined their biological actions in mouse models of parkinson s disease |
| topic | Parkinson’s disease selenium sodium selenite seleno-L-methionine selenoproteins |
| url | https://www.mdpi.com/2072-6643/15/1/11 |
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