Cytokine Production and NET Formation by Monosodium Urate-Activated Human Neutrophils Involves Early and Late Events, and Requires Upstream TAK1 and Syk

Cytokine Production and NET Formation by Monosodium Urate-Activated Human Neutrophils Involves Early and Late Events, and Requires Upstream TAK1 and Syk

Gout is a prevalent and incapacitating disease triggered by the deposition of monosodium urate (MSU) crystals in joints, which are also massively infiltrated by neutrophils. The interaction of the latter with MSU crystals triggers several responses, including the generation of inflammatory mediators...

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Bibliographic Details
Main Authors: Olga Tatsiy, Thomas Z. Mayer, Vanessa de Carvalho Oliveira, Stéphanie Sylvain-Prévost, Marilyn Isabel, Claire M. Dubois, Patrick P. McDonald
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
neutrophils
signaling
cytokines
NETs
transcription factors
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02996/full

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