Topographical similarity of cortical thickness represents generalized anxiety symptoms in adolescence
Generalized anxiety disorder (GAD) is a common condition characterized by excessive and uncontrollable worry, along with its high comorbidity rates. Despite increasing efforts to identify the neural underpinnings of GAD, neuroimaging research using cortical thickness have yielded largely inconsisten...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923023001533 |
| _version_ | 1797677676456050688 |
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| author | Chaebin Yoo M. Justin Kim |
| author_facet | Chaebin Yoo M. Justin Kim |
| author_sort | Chaebin Yoo |
| collection | DOAJ |
| description | Generalized anxiety disorder (GAD) is a common condition characterized by excessive and uncontrollable worry, along with its high comorbidity rates. Despite increasing efforts to identify the neural underpinnings of GAD, neuroimaging research using cortical thickness have yielded largely inconsistent results. To address this, we adopted an inter-subject representational similarity analysis framework to explore a potential nonlinear relationship between vertex-wise cortical thickness and generalized anxiety symptom severity. We utilized a sample of 120 adolescents (13–18 years of age) from the Healthy Brain Network dataset. Here, we found greater topographical resemblance among participants with heightened generalized anxiety symptoms in the left caudal anterior cingulate and pericalcarine cortex. These results were not driven by the effects of age, sex, ADHD diagnosis, and GAD diagnosis. Such associations were not observed when including a group of younger participants (11–12 years of age) for analyses, highlighting the importance of age range selection when considering the link between cortical thickness and anxiety. Our findings reveal a novel cortical thickness topography that represents generalized anxiety in adolescents, which is embedded within the shared geometries between generalized anxiety symptoms and cortical thickness. |
| first_indexed | 2024-03-11T22:48:43Z |
| format | Article |
| id | doaj.art-6f8f624a9218427498243a723e6131b4 |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-03-11T22:48:43Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-6f8f624a9218427498243a723e6131b42023-09-22T04:37:55ZengElsevierBrain Research Bulletin1873-27472023-10-01202110728Topographical similarity of cortical thickness represents generalized anxiety symptoms in adolescenceChaebin Yoo0M. Justin Kim1Department of Psychology, Sungkyunkwan University, Seoul 03063, South Korea; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon 16419, South KoreaDepartment of Psychology, Sungkyunkwan University, Seoul 03063, South Korea; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon 16419, South Korea; Correspondence to: Department of Psychology, Sungkyunkwan University, 25–2 Sungkyunkwan-ro, Jongno-gu, Seoul 03063, South Korea.Generalized anxiety disorder (GAD) is a common condition characterized by excessive and uncontrollable worry, along with its high comorbidity rates. Despite increasing efforts to identify the neural underpinnings of GAD, neuroimaging research using cortical thickness have yielded largely inconsistent results. To address this, we adopted an inter-subject representational similarity analysis framework to explore a potential nonlinear relationship between vertex-wise cortical thickness and generalized anxiety symptom severity. We utilized a sample of 120 adolescents (13–18 years of age) from the Healthy Brain Network dataset. Here, we found greater topographical resemblance among participants with heightened generalized anxiety symptoms in the left caudal anterior cingulate and pericalcarine cortex. These results were not driven by the effects of age, sex, ADHD diagnosis, and GAD diagnosis. Such associations were not observed when including a group of younger participants (11–12 years of age) for analyses, highlighting the importance of age range selection when considering the link between cortical thickness and anxiety. Our findings reveal a novel cortical thickness topography that represents generalized anxiety in adolescents, which is embedded within the shared geometries between generalized anxiety symptoms and cortical thickness.http://www.sciencedirect.com/science/article/pii/S0361923023001533AdolescenceCortical thicknessGeneralized anxietyMRIRepresentational similarity |
| spellingShingle | Chaebin Yoo M. Justin Kim Topographical similarity of cortical thickness represents generalized anxiety symptoms in adolescence Brain Research Bulletin Adolescence Cortical thickness Generalized anxiety MRI Representational similarity |
| title | Topographical similarity of cortical thickness represents generalized anxiety symptoms in adolescence |
| title_full | Topographical similarity of cortical thickness represents generalized anxiety symptoms in adolescence |
| title_fullStr | Topographical similarity of cortical thickness represents generalized anxiety symptoms in adolescence |
| title_full_unstemmed | Topographical similarity of cortical thickness represents generalized anxiety symptoms in adolescence |
| title_short | Topographical similarity of cortical thickness represents generalized anxiety symptoms in adolescence |
| title_sort | topographical similarity of cortical thickness represents generalized anxiety symptoms in adolescence |
| topic | Adolescence Cortical thickness Generalized anxiety MRI Representational similarity |
| url | http://www.sciencedirect.com/science/article/pii/S0361923023001533 |
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