Metabolites of chlorogenic acid and its isomers: Metabolic pathways and activities for ameliorating myocardial hypertrophy
Chlorogenic acid (CGA) has gained considerable attention as pervasive human dietary constituents with potential cardiovascular-preserving effects. CGA and its structural isomers neochlorogenic acid (NCGA), cryptochlorogenic acid (CCGA) possessed potential capacities on improving myocardial hypertrop...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622002869 |
| _version_ | 1828366495691833344 |
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| author | Yanli Chang Kai Huang Fan Yang Yanyan Gao Yan Zhang Sen Li Bin Liu Shuzhen Guo |
| author_facet | Yanli Chang Kai Huang Fan Yang Yanyan Gao Yan Zhang Sen Li Bin Liu Shuzhen Guo |
| author_sort | Yanli Chang |
| collection | DOAJ |
| description | Chlorogenic acid (CGA) has gained considerable attention as pervasive human dietary constituents with potential cardiovascular-preserving effects. CGA and its structural isomers neochlorogenic acid (NCGA), cryptochlorogenic acid (CCGA) possessed potential capacities on improving myocardial hypertrophy. This study aimed to clarify the active metabolites responsible for improving myocardial hypertrophy of CGA, NCGA and CCGA. As a result, similar to in heart, the different metabolites between pathological and myocardial hypertrophy plasma were basically inactive phase Ⅱ metabolites. Finally, 10 metabolites which were accurately identified in CGA, CCGA and NCGA were chosen to be candidates. And the isoproterenol induced H9c2 cells were used as the myocardial hypertrophy model to screen the active metabolites. In conclusion, based on the results of quantification of cardiomyocyte surface area and expression of ANP, BNP and HIF-1α mRNA, caffeic acid, methyl caffeate and dihydrocaffeic acid were identified as the active metabolites. |
| first_indexed | 2024-04-14T05:45:49Z |
| format | Article |
| id | doaj.art-6f9246970ac0494bba954023eaec7a30 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-14T05:45:49Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-6f9246970ac0494bba954023eaec7a302022-12-22T02:09:18ZengElsevierJournal of Functional Foods1756-46462022-09-0196105216Metabolites of chlorogenic acid and its isomers: Metabolic pathways and activities for ameliorating myocardial hypertrophyYanli Chang0Kai Huang1Fan Yang2Yanyan Gao3Yan Zhang4Sen Li5Bin Liu6Shuzhen Guo7School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing, 102488 Beijing, PR ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing, 100029 Beijing, PR ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing, 102488 Beijing, PR ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing, 102488 Beijing, PR ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing, 102488 Beijing, PR ChinaSchool of Life Sciences, Beijing University of Chinese Medicine Beijing, 100029 Beijing, PR ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing, 102488 Beijing, PR China; Corresponding authors at: Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fangshan District, Beijing 102488, China.School of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing, 100029 Beijing, PR China; Corresponding authors at: Northeast Corner of the Intersection of Sunshine South Street and Baiyang East Road, Fangshan District, Beijing 102488, China.Chlorogenic acid (CGA) has gained considerable attention as pervasive human dietary constituents with potential cardiovascular-preserving effects. CGA and its structural isomers neochlorogenic acid (NCGA), cryptochlorogenic acid (CCGA) possessed potential capacities on improving myocardial hypertrophy. This study aimed to clarify the active metabolites responsible for improving myocardial hypertrophy of CGA, NCGA and CCGA. As a result, similar to in heart, the different metabolites between pathological and myocardial hypertrophy plasma were basically inactive phase Ⅱ metabolites. Finally, 10 metabolites which were accurately identified in CGA, CCGA and NCGA were chosen to be candidates. And the isoproterenol induced H9c2 cells were used as the myocardial hypertrophy model to screen the active metabolites. In conclusion, based on the results of quantification of cardiomyocyte surface area and expression of ANP, BNP and HIF-1α mRNA, caffeic acid, methyl caffeate and dihydrocaffeic acid were identified as the active metabolites.http://www.sciencedirect.com/science/article/pii/S1756464622002869Chlorogenic acidsActive metabolitesMyocardial hypertrophy |
| spellingShingle | Yanli Chang Kai Huang Fan Yang Yanyan Gao Yan Zhang Sen Li Bin Liu Shuzhen Guo Metabolites of chlorogenic acid and its isomers: Metabolic pathways and activities for ameliorating myocardial hypertrophy Journal of Functional Foods Chlorogenic acids Active metabolites Myocardial hypertrophy |
| title | Metabolites of chlorogenic acid and its isomers: Metabolic pathways and activities for ameliorating myocardial hypertrophy |
| title_full | Metabolites of chlorogenic acid and its isomers: Metabolic pathways and activities for ameliorating myocardial hypertrophy |
| title_fullStr | Metabolites of chlorogenic acid and its isomers: Metabolic pathways and activities for ameliorating myocardial hypertrophy |
| title_full_unstemmed | Metabolites of chlorogenic acid and its isomers: Metabolic pathways and activities for ameliorating myocardial hypertrophy |
| title_short | Metabolites of chlorogenic acid and its isomers: Metabolic pathways and activities for ameliorating myocardial hypertrophy |
| title_sort | metabolites of chlorogenic acid and its isomers metabolic pathways and activities for ameliorating myocardial hypertrophy |
| topic | Chlorogenic acids Active metabolites Myocardial hypertrophy |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622002869 |
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