A Natural Glucan from Black Bean Inhibits Cancer Cell Proliferation via PI3K-Akt and MAPK Pathway

A Natural Glucan from Black Bean Inhibits Cancer Cell Proliferation via PI3K-Akt and MAPK Pathway

A natural α-1,6-glucan named BBWPW was identified from black beans. Cell viability assay showed that BBWPW inhibited the proliferation of different cancer cells, especially HeLa cells. Flow cytometry analysis indicated that BBWPW suppressed the HeLa cell cycle in the G2/M phase. Consistently, RT-PCR...

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Bibliographic Details
Main Authors: Peng Li, Yihua Hu, Lingmin Zhan, Jiaqi He, Jingwu Lu, Chunyan Gao, Weijun Du, Aiqin Yue, Jinzhong Zhao, Wuxia Zhang
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
black bean
polysaccharide
anti-cancer activity
cell cycle arrest
PI3K/Akt
MAPK
Online Access:https://www.mdpi.com/1420-3049/28/4/1971

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