Fmoc solid-phase synthesis of RF9 optimization with mass spectrometry verification

Fmoc solid-phase synthesis of RF9 optimization with mass spectrometry verification

The RF9 compound, which is an antagonist of the FF neuropeptide receptors is used as a therapeutic substance to improve the effectiveness of opioids in the chronic treatment of pain. The purpose of this study was to find the most efficient method of RF9 synthesis. The optimization experiment involve...

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Bibliographic Details
Main Authors: Orocz Marta, Hartman Kinga, Smoluch Marek, Silberring Jerzy, Mielczarek Przemyslaw
Format: Article
Language:English
Published: Sciendo 2022-07-01
Series:Current Issues in Pharmacy and Medical Sciences
Subjects:
rf9
comu
mass spectrometry
solid-phase synthesis
1-adamantanecarboxylic acid
Online Access:https://doi.org/10.2478/cipms-2022-0003

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