Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression

Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epithelium That Directs P-Glycoprotein Expression

ABSTRACT P-glycoprotein (P-gp) is a key component of the intestinal epithelium playing a pivotal role in removal of toxins and efflux of endocannabinoids to prevent excessive inflammation and sustain homeostasis. Recent studies revealed butyrate and secondary bile acids, produced by the intestinal m...

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Bibliographic Details
Main Authors: Sage E. Foley, Michael J. Dente, Xuqiu Lei, Benjamin F. Sallis, Ethan B. Loew, Mario Meza-Segura, Katherine A. Fitzgerald, Beth A. McCormick
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
P-glycoprotein
multi-drug resistance transporter
microbiome
metabolites
butyrate
short-chain fatty acids
Online Access:https://journals.asm.org/doi/10.1128/mbio.01993-22

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