Syntheses, characterization, and suppression efficiency of silver & silver iodide nanoparticle for proliferation, migration, and invasion in follicular thyroid carcinoma cells
In this study, a chemical co-precipitation method has been employed, silver iodide (AgI NPs) and silver nanoparticles (AgNPs) have been synthesized. UV–vis, FTIR, x-ray diffraction, FESEM, TEM, and other techniques have been used to examine the optical and structural properties of AgNPs and AgI NPs....
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| Format: | Article |
| Language: | English |
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IOP Publishing
2022-01-01
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| Series: | Materials Research Express |
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| Online Access: | https://doi.org/10.1088/2053-1591/ac6d4b |
| _version_ | 1797746336646299648 |
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| author | Saeed M Feyadh Asma H Mohammed |
| author_facet | Saeed M Feyadh Asma H Mohammed |
| author_sort | Saeed M Feyadh |
| collection | DOAJ |
| description | In this study, a chemical co-precipitation method has been employed, silver iodide (AgI NPs) and silver nanoparticles (AgNPs) have been synthesized. UV–vis, FTIR, x-ray diffraction, FESEM, TEM, and other techniques have been used to examine the optical and structural properties of AgNPs and AgI NPs. The UV–vis absorption spectra gave the highest peak at 400 nm for AgNPs and AgI NPs at 434 nm. The x-ray data showed that the prepared AgNPs and AgI NPs were nanocrystalline cubic structures with crystallite sizes of 18 nm and 51 nm, respectively. The FESEM results show that synthesized AgNPs and AgI NPs agglomerate and aggregate. TEM data revealed that AgNPs have a quasi-spherical shape and Gaussian size distribution type. TEM analysis of AgI NPs with different magnifications revealed primarily spherical and well dispersed AgI NPs. TEM histogram shows that the particles were highly monodispersed AgNPs and AgI NPs with an average diameter of 11.5, 24.28 nm, respectively. According to the MTT assay results of FTC133cells, the cytotoxic action IC50 of AgNPs was (52.74 μ g ml ^−1 ) and for AgI nanoparticles was (95.22 μ g ml ^−1 ). It has been found that FTC133 cellular uptake was concentration, size- and time-dependent for both AgNPs and AgI NPs. The migrated FTC133 cell rates were reduced following AgNPs treatment to 75.7% and for AgI NPs treatment to 60% compared with the control group. Furthermore, Invasive FTC133 cell rates were reduced by 60% in the AgNPs treatment group and by 55.71 percent in the AgI NPs treatment group compared to the control group. |
| first_indexed | 2024-03-12T15:36:20Z |
| format | Article |
| id | doaj.art-6f9c09249866429088ccce0330f41418 |
| institution | Directory Open Access Journal |
| issn | 2053-1591 |
| language | English |
| last_indexed | 2024-03-12T15:36:20Z |
| publishDate | 2022-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Materials Research Express |
| spelling | doaj.art-6f9c09249866429088ccce0330f414182023-08-09T16:13:22ZengIOP PublishingMaterials Research Express2053-15912022-01-019505540210.1088/2053-1591/ac6d4bSyntheses, characterization, and suppression efficiency of silver & silver iodide nanoparticle for proliferation, migration, and invasion in follicular thyroid carcinoma cellsSaeed M Feyadh0https://orcid.org/0000-0002-0446-9936Asma H Mohammed1Department of Physics, College of Science, Mustansiriyah University , Baghdad, IraqDepartment of Physics, College of Science, Mustansiriyah University , Baghdad, IraqIn this study, a chemical co-precipitation method has been employed, silver iodide (AgI NPs) and silver nanoparticles (AgNPs) have been synthesized. UV–vis, FTIR, x-ray diffraction, FESEM, TEM, and other techniques have been used to examine the optical and structural properties of AgNPs and AgI NPs. The UV–vis absorption spectra gave the highest peak at 400 nm for AgNPs and AgI NPs at 434 nm. The x-ray data showed that the prepared AgNPs and AgI NPs were nanocrystalline cubic structures with crystallite sizes of 18 nm and 51 nm, respectively. The FESEM results show that synthesized AgNPs and AgI NPs agglomerate and aggregate. TEM data revealed that AgNPs have a quasi-spherical shape and Gaussian size distribution type. TEM analysis of AgI NPs with different magnifications revealed primarily spherical and well dispersed AgI NPs. TEM histogram shows that the particles were highly monodispersed AgNPs and AgI NPs with an average diameter of 11.5, 24.28 nm, respectively. According to the MTT assay results of FTC133cells, the cytotoxic action IC50 of AgNPs was (52.74 μ g ml ^−1 ) and for AgI nanoparticles was (95.22 μ g ml ^−1 ). It has been found that FTC133 cellular uptake was concentration, size- and time-dependent for both AgNPs and AgI NPs. The migrated FTC133 cell rates were reduced following AgNPs treatment to 75.7% and for AgI NPs treatment to 60% compared with the control group. Furthermore, Invasive FTC133 cell rates were reduced by 60% in the AgNPs treatment group and by 55.71 percent in the AgI NPs treatment group compared to the control group.https://doi.org/10.1088/2053-1591/ac6d4bfollicular thyroid cancersilver iodide nanoparticleschemical syntheses |
| spellingShingle | Saeed M Feyadh Asma H Mohammed Syntheses, characterization, and suppression efficiency of silver & silver iodide nanoparticle for proliferation, migration, and invasion in follicular thyroid carcinoma cells Materials Research Express follicular thyroid cancer silver iodide nanoparticles chemical syntheses |
| title | Syntheses, characterization, and suppression efficiency of silver & silver iodide nanoparticle for proliferation, migration, and invasion in follicular thyroid carcinoma cells |
| title_full | Syntheses, characterization, and suppression efficiency of silver & silver iodide nanoparticle for proliferation, migration, and invasion in follicular thyroid carcinoma cells |
| title_fullStr | Syntheses, characterization, and suppression efficiency of silver & silver iodide nanoparticle for proliferation, migration, and invasion in follicular thyroid carcinoma cells |
| title_full_unstemmed | Syntheses, characterization, and suppression efficiency of silver & silver iodide nanoparticle for proliferation, migration, and invasion in follicular thyroid carcinoma cells |
| title_short | Syntheses, characterization, and suppression efficiency of silver & silver iodide nanoparticle for proliferation, migration, and invasion in follicular thyroid carcinoma cells |
| title_sort | syntheses characterization and suppression efficiency of silver silver iodide nanoparticle for proliferation migration and invasion in follicular thyroid carcinoma cells |
| topic | follicular thyroid cancer silver iodide nanoparticles chemical syntheses |
| url | https://doi.org/10.1088/2053-1591/ac6d4b |
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