Comparative efficacy and safety of licensed treatments for previously treated non-small cell lung cancer: A systematic review and network meta-analysis.
PURPOSE:This systematic review with network meta-analysis compared the efficacy and safety of currently licensed second-line treatments in patients with late stage non-small cell lung cancer (NSCLC). METHODS:Randomised controlled trials (RCTs) of participants with advanced/metastatic NSCLC receiving...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6059384?pdf=render |
| _version_ | 1828375855691202560 |
|---|---|
| author | Xavier Armoiry Alexander Tsertsvadze Martin Connock Pamela Royle G J Melendez-Torres Pierre-Jean Souquet Aileen Clarke |
| author_facet | Xavier Armoiry Alexander Tsertsvadze Martin Connock Pamela Royle G J Melendez-Torres Pierre-Jean Souquet Aileen Clarke |
| author_sort | Xavier Armoiry |
| collection | DOAJ |
| description | PURPOSE:This systematic review with network meta-analysis compared the efficacy and safety of currently licensed second-line treatments in patients with late stage non-small cell lung cancer (NSCLC). METHODS:Randomised controlled trials (RCTs) of participants with advanced/metastatic NSCLC receiving second/third line treatments were screened. We searched electronic databases (MEDLINE; EMBASE; Web of Science) from January, 2000 to July, 2017. Two reviewers screened bibliographic records, extracted data, and assessed risk of bias of included studies. The outcomes were overall survival (OS), progression-free survival (PFS), and drug-related grade 3-5 adverse-events (AEs). We pooled study-specific hazard ratios (HR; for OS and PFS) and risk ratios (RR; for AEs) using conventional and network-meta-analyses, and ranked interventions by the surface under the cumulative ranking curve. FINDINGS:We included 11 RCTs (7,581 participants) comparing nine drugs. All drugs except for erlotinib significantly improved OS compared to docetaxel. Nivolumab was the highest ranking drug followed by atezolizumab and pembrolizumab. There was no significant difference in OS across these three drugs (HR = 0.98, 95% CI 0.79, 1.21 for nivolumab vs atezolizumab; HR = 0.98, 95% CI 0.77, 1.25 for nivolumab vs pembrolizumab). For PFS, ramucirumab + docetaxel and nivolumab were the drugs with the highest ranking. All interventions except ramucirumab + docetaxel had a reduced risk for severe drug-related AEs vs. docetaxel. Of the drugs with the highest ranking on AEs, nivolumab was significantly safer compared to atezolizumab (RR = 0.55, 95% CI 0.38, 0.79) or pembrolizumab (RR = 0.52, 95% CI 0.34, 0.81). IMPLICATIONS:Nivolumab, pembrolizumab and atezolizumab exhibited superior benefit/risk balance compared to other licensed drugs used late stage NSCLC. Our results indicate that the use of immunotherapies in people diagnosed with non-specific late stage NSCLC should be promoted. The use of docetaxel may now be judged irrelevant as a comparator intervention for approval of new drugs for second line treatment of NSCLC. STUDY REGISTRATION NUMBER:PROSPERO CRD42017065928. |
| first_indexed | 2024-04-14T07:52:48Z |
| format | Article |
| id | doaj.art-6f9c6c03a13a498693a7a44245807c22 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-14T07:52:48Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6f9c6c03a13a498693a7a44245807c222022-12-22T02:05:09ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01137e019957510.1371/journal.pone.0199575Comparative efficacy and safety of licensed treatments for previously treated non-small cell lung cancer: A systematic review and network meta-analysis.Xavier ArmoiryAlexander TsertsvadzeMartin ConnockPamela RoyleG J Melendez-TorresPierre-Jean SouquetAileen ClarkePURPOSE:This systematic review with network meta-analysis compared the efficacy and safety of currently licensed second-line treatments in patients with late stage non-small cell lung cancer (NSCLC). METHODS:Randomised controlled trials (RCTs) of participants with advanced/metastatic NSCLC receiving second/third line treatments were screened. We searched electronic databases (MEDLINE; EMBASE; Web of Science) from January, 2000 to July, 2017. Two reviewers screened bibliographic records, extracted data, and assessed risk of bias of included studies. The outcomes were overall survival (OS), progression-free survival (PFS), and drug-related grade 3-5 adverse-events (AEs). We pooled study-specific hazard ratios (HR; for OS and PFS) and risk ratios (RR; for AEs) using conventional and network-meta-analyses, and ranked interventions by the surface under the cumulative ranking curve. FINDINGS:We included 11 RCTs (7,581 participants) comparing nine drugs. All drugs except for erlotinib significantly improved OS compared to docetaxel. Nivolumab was the highest ranking drug followed by atezolizumab and pembrolizumab. There was no significant difference in OS across these three drugs (HR = 0.98, 95% CI 0.79, 1.21 for nivolumab vs atezolizumab; HR = 0.98, 95% CI 0.77, 1.25 for nivolumab vs pembrolizumab). For PFS, ramucirumab + docetaxel and nivolumab were the drugs with the highest ranking. All interventions except ramucirumab + docetaxel had a reduced risk for severe drug-related AEs vs. docetaxel. Of the drugs with the highest ranking on AEs, nivolumab was significantly safer compared to atezolizumab (RR = 0.55, 95% CI 0.38, 0.79) or pembrolizumab (RR = 0.52, 95% CI 0.34, 0.81). IMPLICATIONS:Nivolumab, pembrolizumab and atezolizumab exhibited superior benefit/risk balance compared to other licensed drugs used late stage NSCLC. Our results indicate that the use of immunotherapies in people diagnosed with non-specific late stage NSCLC should be promoted. The use of docetaxel may now be judged irrelevant as a comparator intervention for approval of new drugs for second line treatment of NSCLC. STUDY REGISTRATION NUMBER:PROSPERO CRD42017065928.http://europepmc.org/articles/PMC6059384?pdf=render |
| spellingShingle | Xavier Armoiry Alexander Tsertsvadze Martin Connock Pamela Royle G J Melendez-Torres Pierre-Jean Souquet Aileen Clarke Comparative efficacy and safety of licensed treatments for previously treated non-small cell lung cancer: A systematic review and network meta-analysis. PLoS ONE |
| title | Comparative efficacy and safety of licensed treatments for previously treated non-small cell lung cancer: A systematic review and network meta-analysis. |
| title_full | Comparative efficacy and safety of licensed treatments for previously treated non-small cell lung cancer: A systematic review and network meta-analysis. |
| title_fullStr | Comparative efficacy and safety of licensed treatments for previously treated non-small cell lung cancer: A systematic review and network meta-analysis. |
| title_full_unstemmed | Comparative efficacy and safety of licensed treatments for previously treated non-small cell lung cancer: A systematic review and network meta-analysis. |
| title_short | Comparative efficacy and safety of licensed treatments for previously treated non-small cell lung cancer: A systematic review and network meta-analysis. |
| title_sort | comparative efficacy and safety of licensed treatments for previously treated non small cell lung cancer a systematic review and network meta analysis |
| url | http://europepmc.org/articles/PMC6059384?pdf=render |
| work_keys_str_mv | AT xavierarmoiry comparativeefficacyandsafetyoflicensedtreatmentsforpreviouslytreatednonsmallcelllungcancerasystematicreviewandnetworkmetaanalysis AT alexandertsertsvadze comparativeefficacyandsafetyoflicensedtreatmentsforpreviouslytreatednonsmallcelllungcancerasystematicreviewandnetworkmetaanalysis AT martinconnock comparativeefficacyandsafetyoflicensedtreatmentsforpreviouslytreatednonsmallcelllungcancerasystematicreviewandnetworkmetaanalysis AT pamelaroyle comparativeefficacyandsafetyoflicensedtreatmentsforpreviouslytreatednonsmallcelllungcancerasystematicreviewandnetworkmetaanalysis AT gjmelendeztorres comparativeefficacyandsafetyoflicensedtreatmentsforpreviouslytreatednonsmallcelllungcancerasystematicreviewandnetworkmetaanalysis AT pierrejeansouquet comparativeefficacyandsafetyoflicensedtreatmentsforpreviouslytreatednonsmallcelllungcancerasystematicreviewandnetworkmetaanalysis AT aileenclarke comparativeefficacyandsafetyoflicensedtreatmentsforpreviouslytreatednonsmallcelllungcancerasystematicreviewandnetworkmetaanalysis |