Geriatric nutritional risk index was associated with in-hospital mortality among cardiac intensive care unit patients
BackgroundIdentifying risk factors associated with cardiac intensive care unit (CICU) patients’ prognosis can help clinicians intervene earlier and thus improve their prognosis. The correlation between the geriatric nutrition risk index (GNRI), which reflects nutritional status, and in-hospital mort...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1218738/full |
| _version_ | 1797743586283880448 |
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| author | Yuefeng Li Zhengdong Wang Tienan Sun Biyang Zhang Xiangwen Liang |
| author_facet | Yuefeng Li Zhengdong Wang Tienan Sun Biyang Zhang Xiangwen Liang |
| author_sort | Yuefeng Li |
| collection | DOAJ |
| description | BackgroundIdentifying risk factors associated with cardiac intensive care unit (CICU) patients’ prognosis can help clinicians intervene earlier and thus improve their prognosis. The correlation between the geriatric nutrition risk index (GNRI), which reflects nutritional status, and in-hospital mortality among CICU patients has yet to be established.MethodThe present study retrospectively enrolled 4,698 CICU patients. Based on the nutritional status, the participants were categorized into four groups. The primary endpoint was in-hospital mortality. The length of hospital stay and length of CICU stay were the secondary endpoints. To explore the correlation between nutritional status and in-hospital mortality, a logistic regression analysis was conducted. The nonlinear associations of GNRI with in-hospital mortality were evaluated using restricted cubic spline (RCS). Furthermore, subgroup analyses were conducted to evaluate the effect of the GNRI on in-hospital mortality across different subgroups, with calculation of the p for interaction.ResultA higher risk of malnutrition was significantly linked to an increased incidence of in-hospital mortality (High risk vs. No risk: 26.2% vs. 4.6%, p < 0.001), as well as a longer length of hospital stay (High risk vs. No risk: 15.7, 9.1–25.1 vs. 8.9, 6.9–12.9, p < 0.001) and CICU stay (High risk vs. No risk: 6.4, 3.8–11.9 vs. 3.2, 2.3–5.1, p < 0.001). An elevated GNRI was significantly associated with an increased risk of in-hospital mortality even after controlling for pertinent confounding factors (High risk vs. No risk: OR, 95% CI: 2.37, 1.67–3.37, p < 0.001, p for trend <0.001). Additionally, the RCS model showed a linear relationship between GNRI and in-hospital mortality, with the risk of in-hospital mortality significantly decreasing as GNRI increased (non-linear p = 0.596). Furthermore, in the subgroups of hypertension, ventricular arrhythmias, cardiac arrest, shock, and chronic kidney disease, there was a significant interaction between nutritional status and in-hospital mortality.ConclusionAmong CICU patients, a low GNRI was a significant predictor of in-hospital mortality. Furthermore, patients with a higher risk of malnutrition, as indicated by low GNRI values, experienced significantly longer hospital and CICU stays. |
| first_indexed | 2024-03-12T14:57:34Z |
| format | Article |
| id | doaj.art-6f9d305139224d84bae652b64c183b73 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-12T14:57:34Z |
| publishDate | 2023-08-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj.art-6f9d305139224d84bae652b64c183b732023-08-14T12:46:45ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-08-011010.3389/fnut.2023.12187381218738Geriatric nutritional risk index was associated with in-hospital mortality among cardiac intensive care unit patientsYuefeng Li0Zhengdong Wang1Tienan Sun2Biyang Zhang3Xiangwen Liang4The First People’s Hospital of Yulin, Yulin, Guangxi, ChinaThe First People’s Hospital of Yulin, Yulin, Guangxi, ChinaDepartment of Cardiology, Affiliated Anzhen Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Affiliated Anzhen Hospital, Capital Medical University, Beijing, ChinaThe First People’s Hospital of Yulin, Yulin, Guangxi, ChinaBackgroundIdentifying risk factors associated with cardiac intensive care unit (CICU) patients’ prognosis can help clinicians intervene earlier and thus improve their prognosis. The correlation between the geriatric nutrition risk index (GNRI), which reflects nutritional status, and in-hospital mortality among CICU patients has yet to be established.MethodThe present study retrospectively enrolled 4,698 CICU patients. Based on the nutritional status, the participants were categorized into four groups. The primary endpoint was in-hospital mortality. The length of hospital stay and length of CICU stay were the secondary endpoints. To explore the correlation between nutritional status and in-hospital mortality, a logistic regression analysis was conducted. The nonlinear associations of GNRI with in-hospital mortality were evaluated using restricted cubic spline (RCS). Furthermore, subgroup analyses were conducted to evaluate the effect of the GNRI on in-hospital mortality across different subgroups, with calculation of the p for interaction.ResultA higher risk of malnutrition was significantly linked to an increased incidence of in-hospital mortality (High risk vs. No risk: 26.2% vs. 4.6%, p < 0.001), as well as a longer length of hospital stay (High risk vs. No risk: 15.7, 9.1–25.1 vs. 8.9, 6.9–12.9, p < 0.001) and CICU stay (High risk vs. No risk: 6.4, 3.8–11.9 vs. 3.2, 2.3–5.1, p < 0.001). An elevated GNRI was significantly associated with an increased risk of in-hospital mortality even after controlling for pertinent confounding factors (High risk vs. No risk: OR, 95% CI: 2.37, 1.67–3.37, p < 0.001, p for trend <0.001). Additionally, the RCS model showed a linear relationship between GNRI and in-hospital mortality, with the risk of in-hospital mortality significantly decreasing as GNRI increased (non-linear p = 0.596). Furthermore, in the subgroups of hypertension, ventricular arrhythmias, cardiac arrest, shock, and chronic kidney disease, there was a significant interaction between nutritional status and in-hospital mortality.ConclusionAmong CICU patients, a low GNRI was a significant predictor of in-hospital mortality. Furthermore, patients with a higher risk of malnutrition, as indicated by low GNRI values, experienced significantly longer hospital and CICU stays.https://www.frontiersin.org/articles/10.3389/fnut.2023.1218738/fullMIMIC-IV databasecardiac intensive care unitgeriatric nutritional risk indexnutritional statusin-hospital mortality |
| spellingShingle | Yuefeng Li Zhengdong Wang Tienan Sun Biyang Zhang Xiangwen Liang Geriatric nutritional risk index was associated with in-hospital mortality among cardiac intensive care unit patients Frontiers in Nutrition MIMIC-IV database cardiac intensive care unit geriatric nutritional risk index nutritional status in-hospital mortality |
| title | Geriatric nutritional risk index was associated with in-hospital mortality among cardiac intensive care unit patients |
| title_full | Geriatric nutritional risk index was associated with in-hospital mortality among cardiac intensive care unit patients |
| title_fullStr | Geriatric nutritional risk index was associated with in-hospital mortality among cardiac intensive care unit patients |
| title_full_unstemmed | Geriatric nutritional risk index was associated with in-hospital mortality among cardiac intensive care unit patients |
| title_short | Geriatric nutritional risk index was associated with in-hospital mortality among cardiac intensive care unit patients |
| title_sort | geriatric nutritional risk index was associated with in hospital mortality among cardiac intensive care unit patients |
| topic | MIMIC-IV database cardiac intensive care unit geriatric nutritional risk index nutritional status in-hospital mortality |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1218738/full |
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