Rescue of Noradrenergic System as a Novel Pharmacological Strategy in the Treatment of Chronic Pain: Focus on Microglia Activation

Rescue of Noradrenergic System as a Novel Pharmacological Strategy in the Treatment of Chronic Pain: Focus on Microglia Activation

Different types of pain can evolve toward a chronic condition characterized by hyperalgesia and allodynia, with an abnormal response to normal or even innocuous stimuli, respectively. A key role in endogenous analgesia is recognized to descending noradrenergic pathways that originate from the locus...

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Bibliographic Details
Main Authors: Filippo Caraci, Sara Merlo, Filippo Drago, Giuseppe Caruso, Carmela Parenti, Maria Angela Sortino
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Pharmacology
Subjects:
neuropathic pain
neuroinflammation
microglia
noradrenaline reuptake inhibitors
µ-opioid receptor agonists
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01024/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.01024/full

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