Melon juice concentrate supplementation in an animal model of obesity: Involvement of relaxin and fatty acid pathways
Chronic low-grade inflammation and oxidative stress associated with obesity induce molecular changes in extracellular matrix connected to relaxin pathway and fibrosis, the lipidome of various tissues and the level of lipid mediators. Increase of desaturase enzymatic activity and activation of the in...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619302890 |
| _version_ | 1818953995989811200 |
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| author | Julie Carillon Marion Saby Sandy Barial Anna Sansone Roberta Scanferlato Nathalie Gayrard Anne-Dominique Lajoix Bernard Jover Chryssostomos Chatgilialoglu Carla Ferreri |
| author_facet | Julie Carillon Marion Saby Sandy Barial Anna Sansone Roberta Scanferlato Nathalie Gayrard Anne-Dominique Lajoix Bernard Jover Chryssostomos Chatgilialoglu Carla Ferreri |
| author_sort | Julie Carillon |
| collection | DOAJ |
| description | Chronic low-grade inflammation and oxidative stress associated with obesity induce molecular changes in extracellular matrix connected to relaxin pathway and fibrosis, the lipidome of various tissues and the level of lipid mediators. Increase of desaturase enzymatic activity and activation of the inflammatory mediator cascades are known to be associated with obesity. Decrease of enzymatic antioxidant defenses is strictly involved. The effects of a 10 days supplementation of encapsulated melon juice concentrate rich in superoxide dismutase were studied in Zucker Fat rats compared with Zucker Lean rats, following relaxin pathways, lipid mediators and fatty acid-based lipidomic analysis in adipose tissue and erythrocytes. Significant ameliorations in obese rats concerned the restored relaxin levels, connected with fibrosis reduction, the reduction of inflammatory mediators and a favorable fatty acid remodeling, with the decrease of unsaturated fatty acids in the lipidome of adipose tissue and erythrocytes becoming closer to the lipidome of normal rats. |
| first_indexed | 2024-12-20T10:15:08Z |
| format | Article |
| id | doaj.art-6f9f834c70804b2e9c1e95ea8c2e7573 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T10:15:08Z |
| publishDate | 2019-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-6f9f834c70804b2e9c1e95ea8c2e75732022-12-21T19:44:06ZengElsevierJournal of Functional Foods1756-46462019-08-015992100Melon juice concentrate supplementation in an animal model of obesity: Involvement of relaxin and fatty acid pathwaysJulie Carillon0Marion Saby1Sandy Barial2Anna Sansone3Roberta Scanferlato4Nathalie Gayrard5Anne-Dominique Lajoix6Bernard Jover7Chryssostomos Chatgilialoglu8Carla Ferreri9EA7288 Université de Montpellier, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, France; Bionov Sarl, Site Agroparc, Batiment Orion, Chemin des Meinajaries, CS 80501, Cedex 9, Avignon 84908 FranceEA7288 Université de Montpellier, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, FranceEA7288 Université de Montpellier, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, FranceISOF, Consiglio Nazionale delle Ricerche, Via Piero Gobetti 101, 40129 Bologna, ItalyISOF, Consiglio Nazionale delle Ricerche, Via Piero Gobetti 101, 40129 Bologna, ItalyEA7288 Université de Montpellier, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, FranceEA7288 Université de Montpellier, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, FranceEA7288 Université de Montpellier, 15 Avenue Charles Flahault, BP 14491, 34093 Montpellier Cedex 5, FranceISOF, Consiglio Nazionale delle Ricerche, Via Piero Gobetti 101, 40129 Bologna, ItalyISOF, Consiglio Nazionale delle Ricerche, Via Piero Gobetti 101, 40129 Bologna, Italy; Corresponding author.Chronic low-grade inflammation and oxidative stress associated with obesity induce molecular changes in extracellular matrix connected to relaxin pathway and fibrosis, the lipidome of various tissues and the level of lipid mediators. Increase of desaturase enzymatic activity and activation of the inflammatory mediator cascades are known to be associated with obesity. Decrease of enzymatic antioxidant defenses is strictly involved. The effects of a 10 days supplementation of encapsulated melon juice concentrate rich in superoxide dismutase were studied in Zucker Fat rats compared with Zucker Lean rats, following relaxin pathways, lipid mediators and fatty acid-based lipidomic analysis in adipose tissue and erythrocytes. Significant ameliorations in obese rats concerned the restored relaxin levels, connected with fibrosis reduction, the reduction of inflammatory mediators and a favorable fatty acid remodeling, with the decrease of unsaturated fatty acids in the lipidome of adipose tissue and erythrocytes becoming closer to the lipidome of normal rats.http://www.sciencedirect.com/science/article/pii/S1756464619302890Superoxide dismutaseAdipose tissueMembrane lipidomeInflammatory mediatorsFibrosisLipid remodeling |
| spellingShingle | Julie Carillon Marion Saby Sandy Barial Anna Sansone Roberta Scanferlato Nathalie Gayrard Anne-Dominique Lajoix Bernard Jover Chryssostomos Chatgilialoglu Carla Ferreri Melon juice concentrate supplementation in an animal model of obesity: Involvement of relaxin and fatty acid pathways Journal of Functional Foods Superoxide dismutase Adipose tissue Membrane lipidome Inflammatory mediators Fibrosis Lipid remodeling |
| title | Melon juice concentrate supplementation in an animal model of obesity: Involvement of relaxin and fatty acid pathways |
| title_full | Melon juice concentrate supplementation in an animal model of obesity: Involvement of relaxin and fatty acid pathways |
| title_fullStr | Melon juice concentrate supplementation in an animal model of obesity: Involvement of relaxin and fatty acid pathways |
| title_full_unstemmed | Melon juice concentrate supplementation in an animal model of obesity: Involvement of relaxin and fatty acid pathways |
| title_short | Melon juice concentrate supplementation in an animal model of obesity: Involvement of relaxin and fatty acid pathways |
| title_sort | melon juice concentrate supplementation in an animal model of obesity involvement of relaxin and fatty acid pathways |
| topic | Superoxide dismutase Adipose tissue Membrane lipidome Inflammatory mediators Fibrosis Lipid remodeling |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619302890 |
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