The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi.
The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also...
Main Authors: | Joppe W R Hovius, Maarten F Bijlsma, Gerritje J W van der Windt, W Joost Wiersinga, Bastiaan J D Boukens, Jeroen Coumou, Anneke Oei, Regina de Beer, Alex F de Vos, Cornelis van 't Veer, Alje P van Dam, Penghua Wang, Erol Fikrig, Marcel M Levi, Joris J T H Roelofs, Tom van der Poll |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2009-05-01
|
Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC2678258?pdf=render |
Similar Items
-
A tick gut protein with fibronectin III domains aids Borrelia burgdorferi congregation to the gut during transmission.
by: Sukanya Narasimhan, et al.
Published: (2014-08-01) -
Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis.
by: Wiersinga, W, et al.
Published: (2010) -
Borrelia burgdorferi Induces TLR2-Mediated Migration of Activated Dendritic Cells in an Ex Vivo Human Skin Model.
by: Lauren M K Mason, et al.
Published: (2016-01-01) -
Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization
by: Sukanya Narasimhan, et al.
Published: (2017-08-01) -
Tick-Tattoo: DNA Vaccination Against B. burgdorferi or Ixodes scapularis Tick Proteins
by: Michelle J. Klouwens, et al.
Published: (2021-02-01)