Intratumor Heterogeneity Correlates With Reduced Immune Activity and Worse Survival in Melanoma Patients

Intratumor Heterogeneity Correlates With Reduced Immune Activity and Worse Survival in Melanoma Patients

BackgroundHuman malignant melanoma is a highly aggressive, heterogeneous and drug-resistant cancer. Due to a high number of clones, harboring various mutations that affect key pathways, there is an exceptional level of phenotypic variation and intratumor heterogeneity (ITH) in melanoma. This poses a...

Full description

Bibliographic Details
Main Authors: Zhen Lin, Xianyi Meng, Jinming Wen, José María Corral, Darja Andreev, Katerina Kachler, Georg Schett, Xiaoxiang Chen, Aline Bozec
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
immunomodulator
intratumor heterogeneity
The Cancer Genome Atlas
tumor infiltrating lymphocytes
melanoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.596493/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.596493/full

Similar Items