Intratumor Heterogeneity Correlates With Reduced Immune Activity and Worse Survival in Melanoma Patients

Intratumor Heterogeneity Correlates With Reduced Immune Activity and Worse Survival in Melanoma Patients

BackgroundHuman malignant melanoma is a highly aggressive, heterogeneous and drug-resistant cancer. Due to a high number of clones, harboring various mutations that affect key pathways, there is an exceptional level of phenotypic variation and intratumor heterogeneity (ITH) in melanoma. This poses a...

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Bibliographic Details
Main Authors: Zhen Lin, Xianyi Meng, Jinming Wen, José María Corral, Darja Andreev, Katerina Kachler, Georg Schett, Xiaoxiang Chen, Aline Bozec
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
immunomodulator
intratumor heterogeneity
The Cancer Genome Atlas
tumor infiltrating lymphocytes
melanoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.596493/full

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