An overview of FSH-FSHR biology and explaining the existing conundrums
Abstract FSH was first identified in 1930 and is central to mammalian reproduction. It is indeed intriguing that despite being researched upon for about 90 years, there is still so much more to learn about FSH-FSHR biology. The purpose of this review is to provide an overview of current understandin...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2021-10-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13048-021-00880-3 |
| _version_ | 1797969842352947200 |
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| author | Deepa Bhartiya Hiren Patel |
| author_facet | Deepa Bhartiya Hiren Patel |
| author_sort | Deepa Bhartiya |
| collection | DOAJ |
| description | Abstract FSH was first identified in 1930 and is central to mammalian reproduction. It is indeed intriguing that despite being researched upon for about 90 years, there is still so much more to learn about FSH-FSHR biology. The purpose of this review is to provide an overview of current understanding of FSH-FSHR biology, to review published data on biological and clinical relevance of reported mutations, polymorphisms and alternately spliced isoforms of FSHR. Tissue-resident stem/progenitor cells in multiple adult tissues including ovaries, testes and uterus express FSHR and this observation results in a paradigm shift in the field. The results suggest a direct action of FSH on the stem cells in addition to their well-studied action on Granulosa and Sertoli cells in the ovaries and testes respectively. Present review further addresses various concerns raised in recent times by the scientific community regarding extragonadal expression of FSHR, especially in cancers affecting multiple organs. Similar population of primitive and pluripotent tissue-resident stem cells expressing FSHR exist in multiple adult tissues including bone marrow and reproductive tissues and help maintain homeostasis throughout life. Any dysfunction of these stem cells results in various pathologies and they also most likely get transformed into cancer stem cells and initiate cancer. This explains why multiple solid as well as liquid tumors express OCT-4 and FSHR. More research efforts need to be focused on alternately spliced FSHR isoforms. |
| first_indexed | 2024-04-11T03:08:22Z |
| format | Article |
| id | doaj.art-6fa0937e11b44ee885c61c0c18109da1 |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:08:22Z |
| publishDate | 2021-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-6fa0937e11b44ee885c61c0c18109da12023-01-02T12:32:12ZengBMCJournal of Ovarian Research1757-22152021-10-0114111410.1186/s13048-021-00880-3An overview of FSH-FSHR biology and explaining the existing conundrumsDeepa Bhartiya0Hiren Patel1Stem Cell Biology Department, ICMR- National Institute for Research in Reproductive HealthStem Cell Biology Department, ICMR- National Institute for Research in Reproductive HealthAbstract FSH was first identified in 1930 and is central to mammalian reproduction. It is indeed intriguing that despite being researched upon for about 90 years, there is still so much more to learn about FSH-FSHR biology. The purpose of this review is to provide an overview of current understanding of FSH-FSHR biology, to review published data on biological and clinical relevance of reported mutations, polymorphisms and alternately spliced isoforms of FSHR. Tissue-resident stem/progenitor cells in multiple adult tissues including ovaries, testes and uterus express FSHR and this observation results in a paradigm shift in the field. The results suggest a direct action of FSH on the stem cells in addition to their well-studied action on Granulosa and Sertoli cells in the ovaries and testes respectively. Present review further addresses various concerns raised in recent times by the scientific community regarding extragonadal expression of FSHR, especially in cancers affecting multiple organs. Similar population of primitive and pluripotent tissue-resident stem cells expressing FSHR exist in multiple adult tissues including bone marrow and reproductive tissues and help maintain homeostasis throughout life. Any dysfunction of these stem cells results in various pathologies and they also most likely get transformed into cancer stem cells and initiate cancer. This explains why multiple solid as well as liquid tumors express OCT-4 and FSHR. More research efforts need to be focused on alternately spliced FSHR isoforms.https://doi.org/10.1186/s13048-021-00880-3FSHFSHRIsoformsMutationsSNPsOvary |
| spellingShingle | Deepa Bhartiya Hiren Patel An overview of FSH-FSHR biology and explaining the existing conundrums Journal of Ovarian Research FSH FSHR Isoforms Mutations SNPs Ovary |
| title | An overview of FSH-FSHR biology and explaining the existing conundrums |
| title_full | An overview of FSH-FSHR biology and explaining the existing conundrums |
| title_fullStr | An overview of FSH-FSHR biology and explaining the existing conundrums |
| title_full_unstemmed | An overview of FSH-FSHR biology and explaining the existing conundrums |
| title_short | An overview of FSH-FSHR biology and explaining the existing conundrums |
| title_sort | overview of fsh fshr biology and explaining the existing conundrums |
| topic | FSH FSHR Isoforms Mutations SNPs Ovary |
| url | https://doi.org/10.1186/s13048-021-00880-3 |
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