Survival after surgical resection of distal cholangiocarcinoma: A systematic review and meta-analysis of prognostic factors
Background/Objective: This study aimed to assess the available evidence on the survival of distal cholangiocarcinoma (DCC) patients following resection with curative intent and analyze the prognostic factors. Methods: Relevant studies published between January 2000 and January 2015 were identified b...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-03-01
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| Series: | Asian Journal of Surgery |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1015958415000858 |
| _version_ | 1818522745454985216 |
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| author | Yanming Zhou Shuncui Liu Lupeng Wu Tao Wan |
| author_facet | Yanming Zhou Shuncui Liu Lupeng Wu Tao Wan |
| author_sort | Yanming Zhou |
| collection | DOAJ |
| description | Background/Objective: This study aimed to assess the available evidence on the survival of distal cholangiocarcinoma (DCC) patients following resection with curative intent and analyze the prognostic factors.
Methods: Relevant studies published between January 2000 and January 2015 were identified by searching PubMed and Embase and reviewed systematically. Summary relative risks (RR) and 95% confidence intervals (95% CI) were estimated using random-effects models.
Results: A total of 39 observational studies involving 3258 patients were included in the review. R0 resection was achieved in 84% (range, 46–100%) of patients. The median 5-year overall survival rate after resection was 37% (range, 13–54%), with corresponding rate of 44% (range, 27–63%) in R0 resection. The meta-analysis for 25 studies showed that R1 resection (RR 2.36, 95% CI 1.89–2.93), lymph node metastasis (RR 2.35, 95% CI 1.89–2.93), perineural invasion (RR 1.96, 95% CI 1.64–2.34), lymphatic invasion (RR 1.84, 95% CI 1.47–2.31), vascular invasion (RR 1.99, 95% CI 1.40–2.82), pancreatic invasion (RR 2.13, 95% CI 1.39–3.27), and pathological tumor stage ≥ T3 (RR 1.56, 95% CI 1.25–1.93) were associated with shorter survival.
Conclusion: In general, prognosis of DCC after resection is poor. R0 resection results in a substantially improved survival and represents one of the most important prognostic variables. |
| first_indexed | 2024-12-11T05:37:06Z |
| format | Article |
| id | doaj.art-6fa0b8c08bda4e16a12dde002e883af5 |
| institution | Directory Open Access Journal |
| issn | 1015-9584 |
| language | English |
| last_indexed | 2024-12-11T05:37:06Z |
| publishDate | 2017-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Surgery |
| spelling | doaj.art-6fa0b8c08bda4e16a12dde002e883af52022-12-22T01:19:15ZengElsevierAsian Journal of Surgery1015-95842017-03-0140212913810.1016/j.asjsur.2015.07.002Survival after surgical resection of distal cholangiocarcinoma: A systematic review and meta-analysis of prognostic factorsYanming ZhouShuncui LiuLupeng WuTao WanBackground/Objective: This study aimed to assess the available evidence on the survival of distal cholangiocarcinoma (DCC) patients following resection with curative intent and analyze the prognostic factors. Methods: Relevant studies published between January 2000 and January 2015 were identified by searching PubMed and Embase and reviewed systematically. Summary relative risks (RR) and 95% confidence intervals (95% CI) were estimated using random-effects models. Results: A total of 39 observational studies involving 3258 patients were included in the review. R0 resection was achieved in 84% (range, 46–100%) of patients. The median 5-year overall survival rate after resection was 37% (range, 13–54%), with corresponding rate of 44% (range, 27–63%) in R0 resection. The meta-analysis for 25 studies showed that R1 resection (RR 2.36, 95% CI 1.89–2.93), lymph node metastasis (RR 2.35, 95% CI 1.89–2.93), perineural invasion (RR 1.96, 95% CI 1.64–2.34), lymphatic invasion (RR 1.84, 95% CI 1.47–2.31), vascular invasion (RR 1.99, 95% CI 1.40–2.82), pancreatic invasion (RR 2.13, 95% CI 1.39–3.27), and pathological tumor stage ≥ T3 (RR 1.56, 95% CI 1.25–1.93) were associated with shorter survival. Conclusion: In general, prognosis of DCC after resection is poor. R0 resection results in a substantially improved survival and represents one of the most important prognostic variables.http://www.sciencedirect.com/science/article/pii/S1015958415000858distal cholangiocarcinomaprognostic factorsresectionsurvival |
| spellingShingle | Yanming Zhou Shuncui Liu Lupeng Wu Tao Wan Survival after surgical resection of distal cholangiocarcinoma: A systematic review and meta-analysis of prognostic factors Asian Journal of Surgery distal cholangiocarcinoma prognostic factors resection survival |
| title | Survival after surgical resection of distal cholangiocarcinoma: A systematic review and meta-analysis of prognostic factors |
| title_full | Survival after surgical resection of distal cholangiocarcinoma: A systematic review and meta-analysis of prognostic factors |
| title_fullStr | Survival after surgical resection of distal cholangiocarcinoma: A systematic review and meta-analysis of prognostic factors |
| title_full_unstemmed | Survival after surgical resection of distal cholangiocarcinoma: A systematic review and meta-analysis of prognostic factors |
| title_short | Survival after surgical resection of distal cholangiocarcinoma: A systematic review and meta-analysis of prognostic factors |
| title_sort | survival after surgical resection of distal cholangiocarcinoma a systematic review and meta analysis of prognostic factors |
| topic | distal cholangiocarcinoma prognostic factors resection survival |
| url | http://www.sciencedirect.com/science/article/pii/S1015958415000858 |
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