Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF
Enhancer RNAs (eRNAs) can stimulate gene transcription through various mechanisms. Here, the authors identify the molecular features within eRNAs that are critical for their action in facilitating RNA Polymerase II release from the paused state.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29934-w |
| _version_ | 1818191248873226240 |
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| author | Vladyslava Gorbovytska Seung-Kyoon Kim Filiz Kuybu Michael Götze Dahun Um Keunsoo Kang Andreas Pittroff Theresia Brennecke Lisa-Marie Schneider Alexander Leitner Tae-Kyung Kim Claus-D. Kuhn |
| author_facet | Vladyslava Gorbovytska Seung-Kyoon Kim Filiz Kuybu Michael Götze Dahun Um Keunsoo Kang Andreas Pittroff Theresia Brennecke Lisa-Marie Schneider Alexander Leitner Tae-Kyung Kim Claus-D. Kuhn |
| author_sort | Vladyslava Gorbovytska |
| collection | DOAJ |
| description | Enhancer RNAs (eRNAs) can stimulate gene transcription through various mechanisms. Here, the authors identify the molecular features within eRNAs that are critical for their action in facilitating RNA Polymerase II release from the paused state. |
| first_indexed | 2024-12-12T00:11:36Z |
| format | Article |
| id | doaj.art-6fa17c70dad745c2a97c60a4d135cbda |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T00:11:36Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6fa17c70dad745c2a97c60a4d135cbda2022-12-22T00:44:58ZengNature PortfolioNature Communications2041-17232022-05-0113112210.1038/s41467-022-29934-wEnhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELFVladyslava Gorbovytska0Seung-Kyoon Kim1Filiz Kuybu2Michael Götze3Dahun Um4Keunsoo Kang5Andreas Pittroff6Theresia Brennecke7Lisa-Marie Schneider8Alexander Leitner9Tae-Kyung Kim10Claus-D. Kuhn11RNA Biochemistry, University of BayreuthDepartment of Life Sciences, Pohang University of Science and Technology (POSTECH)RNA Biochemistry, University of BayreuthDepartment of Biology, Institute of Molecular Systems Biology, ETH ZurichDepartment of Life Sciences, Pohang University of Science and Technology (POSTECH)Department of Microbiology, Dankook UniversityRNA Biochemistry, University of BayreuthRNA Biochemistry, University of BayreuthRNA Biochemistry, University of BayreuthDepartment of Biology, Institute of Molecular Systems Biology, ETH ZurichDepartment of Life Sciences, Pohang University of Science and Technology (POSTECH)RNA Biochemistry, University of BayreuthEnhancer RNAs (eRNAs) can stimulate gene transcription through various mechanisms. Here, the authors identify the molecular features within eRNAs that are critical for their action in facilitating RNA Polymerase II release from the paused state.https://doi.org/10.1038/s41467-022-29934-w |
| spellingShingle | Vladyslava Gorbovytska Seung-Kyoon Kim Filiz Kuybu Michael Götze Dahun Um Keunsoo Kang Andreas Pittroff Theresia Brennecke Lisa-Marie Schneider Alexander Leitner Tae-Kyung Kim Claus-D. Kuhn Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF Nature Communications |
| title | Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF |
| title_full | Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF |
| title_fullStr | Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF |
| title_full_unstemmed | Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF |
| title_short | Enhancer RNAs stimulate Pol II pause release by harnessing multivalent interactions to NELF |
| title_sort | enhancer rnas stimulate pol ii pause release by harnessing multivalent interactions to nelf |
| url | https://doi.org/10.1038/s41467-022-29934-w |
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