Laboratory Diagnosis of von Willebrand's Disease
von Willebrand's disease (vWD) is an autosomally inherited bleeding disorder caused by a deficiency or abnormality of von Willebrand factor (vWF). vWF is a multimeric adhesive protein that plays an important role in primary hemostasis by promoting platelet adhesion to the subendothelium at the...
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| Format: | Article |
| Language: | English |
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Secretariat of The Indonesian Biomedical Journal
2009-12-01
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| Series: | Indonesian Biomedical Journal |
| Online Access: | http://inabj.org/index.php/ibj/article/view/100 |
| _version_ | 1817986387063865344 |
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| author | Mansyur Arif |
| author_facet | Mansyur Arif |
| author_sort | Mansyur Arif |
| collection | DOAJ |
| description | von Willebrand's disease (vWD) is an autosomally inherited bleeding disorder caused by a deficiency or abnormality of von Willebrand factor (vWF). vWF is a multimeric adhesive protein that plays an important role in primary hemostasis by promoting platelet adhesion to the subendothelium at the sites of vascular injury. It is also the carrier of factor VIII (FVIII), thus indirectly contributing to the coagulation process. Bleeding symptoms are usually mucocutaneous and postsurgical with varying severity. The diagnosis of vWD requires a personal and family history of bleeding and confirmation by laboratory analysis involving vWF antigen level, vWF ristocetin cofactor, FVIII activity, ristocetin-induced platelet aggregation, and vWF multimer analysis. KEYWORDS: von Willebrand's disease, von Willebrand factor. |
| first_indexed | 2024-04-14T00:08:46Z |
| format | Article |
| id | doaj.art-6fa21edacf2640f4ac156f5b0982d4f1 |
| institution | Directory Open Access Journal |
| issn | 2085-3297 2355-9179 |
| language | English |
| last_indexed | 2024-04-14T00:08:46Z |
| publishDate | 2009-12-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj.art-6fa21edacf2640f4ac156f5b0982d4f12022-12-22T02:23:25ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792009-12-0113576410.18585/inabj.v1i3.10092Laboratory Diagnosis of von Willebrand's DiseaseMansyur Arif0Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University Jl. Perintis Kemerdekaan Km.100, Makassarvon Willebrand's disease (vWD) is an autosomally inherited bleeding disorder caused by a deficiency or abnormality of von Willebrand factor (vWF). vWF is a multimeric adhesive protein that plays an important role in primary hemostasis by promoting platelet adhesion to the subendothelium at the sites of vascular injury. It is also the carrier of factor VIII (FVIII), thus indirectly contributing to the coagulation process. Bleeding symptoms are usually mucocutaneous and postsurgical with varying severity. The diagnosis of vWD requires a personal and family history of bleeding and confirmation by laboratory analysis involving vWF antigen level, vWF ristocetin cofactor, FVIII activity, ristocetin-induced platelet aggregation, and vWF multimer analysis. KEYWORDS: von Willebrand's disease, von Willebrand factor.http://inabj.org/index.php/ibj/article/view/100 |
| spellingShingle | Mansyur Arif Laboratory Diagnosis of von Willebrand's Disease Indonesian Biomedical Journal |
| title | Laboratory Diagnosis of von Willebrand's Disease |
| title_full | Laboratory Diagnosis of von Willebrand's Disease |
| title_fullStr | Laboratory Diagnosis of von Willebrand's Disease |
| title_full_unstemmed | Laboratory Diagnosis of von Willebrand's Disease |
| title_short | Laboratory Diagnosis of von Willebrand's Disease |
| title_sort | laboratory diagnosis of von willebrand s disease |
| url | http://inabj.org/index.php/ibj/article/view/100 |
| work_keys_str_mv | AT mansyurarif laboratorydiagnosisofvonwillebrandsdisease |