Peritumoral tertiary lymphoid structure and tumor stroma percentage predict the prognosis of patients with non-metastatic colorectal cancer

Peritumoral tertiary lymphoid structure and tumor stroma percentage predict the prognosis of patients with non-metastatic colorectal cancer

BackgroundTertiary lymphoid structures (TLSs) are crucial in promoting and maintaining positive anti-tumor immune responses. The tumor stroma has a powerful immunosuppressive function that could exclude tumor-infiltrating lymphocytes from the tumor beds and lead to a “cold” phenotype. TLSs and tumor...

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Bibliographic Details
Main Authors: Qianyu Wang, Xiaofei Shen, Ran An, Junchao Bai, Junhua Dong, Huiyun Cai, Hongyan Zhu, Wentao Zhong, Wenliang Chen, Aijun Liu, Junfeng Du
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
tumor immune microenvironment
tertiary lymphoid structures (TLS)
tumor stroma percentage
nomogram
prognosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.962056/full

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