13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity against Oral Cancer Cells through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts

13-Acetoxysarcocrassolide Exhibits Cytotoxic Activity against Oral Cancer Cells through the Interruption of the Keap1/Nrf2/p62/SQSTM1 Pathway: The Need to Move Beyond Classical Concepts

13-Acetoxysarcocrassolide (13-AC), a marine cytotoxic product isolated from the alcyonacean coral <i>Lobophytum crassum</i>, exhibited potent antitumor and immunostimulant effects as reported in previous studies. However, the 13-AC antitumor mechanism of action against oral cancer cells...

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Bibliographic Details
Main Authors: Yi-Chang Liu, Bo-Rong Peng, Kai-Cheng Hsu, Mohamed El-Shazly, Shou-Ping Shih, Tony Eight Lin, Fu-Wen Kuo, Yi-Cheng Chou, Hung-Yu Lin, Mei-Chin Lu
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Marine Drugs
Subjects:
apoptosis
reactive oxygen species
13-Acetoxysarcocrassolide
oral cancer
oxidative stress
Keap1/Nrf2/p62/SQSTM1
Online Access:https://www.mdpi.com/1660-3397/18/8/382

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